S0508
磺胺间甲氧嘧啶
别名:
4-氨基-N-(6-甲氧基-4-嘧啶基)苯磺酰胺, 4-甲氧基-6-磺胺嘧啶, N1-(6-甲氧基-4-嘧啶基)磺胺, SMM
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关于此项目
经验公式（希尔记法）:
C11H12N4O3S
化学文摘社编号:
分子量:
280.30
UNSPSC Code:
51283946
NACRES:
NA.85
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
621128
InChI
1S/C11H12N4O3S/c1-18-11-6-10(13-7-14-11)15-19(16,17)9-4-2-8(12)3-5-9/h2-7H,12H2,1H3,(H,13,14,15)
SMILES string
COc1cc(NS(=O)(=O)c2ccc(N)cc2)ncn1
InChI key
WMPXPUYPYQKQCX-UHFFFAOYSA-N
form
powder
color
white to yellow-white
solubility
methanol: soluble 10 mg/mL
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria, parasites
mode of action
DNA synthesis | interferes, enzyme | inhibits
Quality Level
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General description
化学结构：磺胺
Application
磺胺间甲氧嘧啶可用于研究Fe3O4磁性纳米颗粒介导的降解。 可用于血液动力学研究支气管炎鲍特氏菌(Bordetella bronchiseptica)的荚膜形成。
Biochem/physiol Actions
磺胺间甲氧嘧啶是二氢喋呤合成酶的竞争性抑制剂，用于阻断叶酸的合成。
Other Notes
保存于密闭容器内，置于干燥通风处。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
A Kuwano
Zentralblatt fur Veterinarmedizin. Reihe B. Journal of veterinary medicine. Series B, 38(9), 685-688 (1991-11-01)
Bordetella bronchiseptica phase I organism possesses a capsule and has the ability to agglutinate with K antiserum, although phase III organism lacks both. The present study examines the effect of sulfamonomethoxine (SMMX) on capsule formation of B. bronchiseptica. I also
Thomas Trolle et al.
Bioinformatics (Oxford, England), 31(13), 2174-2181 (2015-02-27)
Numerous in silico methods predicting peptide binding to major histocompatibility complex (MHC) class I molecules have been developed over the last decades. However, the multitude of available prediction tools makes it non-trivial for the end-user to select which tool to
C Girardi et al.
Pharmacological research, 22(2), 79-86 (1990-03-01)
Intrauterine administration was performed in six Friesan cows with a disposable spray preparation containing 3 g of sulfamonomethoxine and 3 g of oxytetracycline, in order to investigate their serum kinetics. Sulfamonomethoxine levels were determined by a reversed-phase HPLC method, whilst
G Zhang et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 25(4), 413-423 (2008-03-19)
A rapid lateral flow immunoassay screening method has been developed for the determination of sulfamonomethoxine (SMM) residues in swine urine. For this purpose, a specific monoclonal antibody (mAb), SMM4B9 for SMM, was generated and characterized. The mAb showed low cross-reactivity
Caixia Jin et al.
Ecotoxicology (London, England), 18(7), 878-885 (2009-06-26)
Investigation of the toxic effects of three veterinary drugs [sulfadiazine sodium (SDS), sulfamonomethoxine sodium (SMMS), and enrofloxacin (EFLX)] on seed germination, root elongation and shoot elongation of wheat (Triticum aestivum L.), Chinese cabbage (Brassica campestris L.) and tomato (Cyphomandra betacea)
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