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S0508

Sigma-Aldrich

磺胺间甲氧嘧啶

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别名:
4-氨基-N-(6-甲氧基-4-嘧啶基)苯磺酰胺, 4-甲氧基-6-磺胺嘧啶, N1-(6-甲氧基-4-嘧啶基)磺胺, SMM
经验公式（希尔记法）:
C11H12N4O3S
CAS号:
1220-83-3
分子量:
280.30
Beilstein:
621128
MDL编号:
MFCD00063466
PubChem化学物质编号:
24899439
NACRES:
NA.85

形式

powder

质量水平

200

颜色

white to yellow-white

溶解性

methanol: soluble 10 mg/mL

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria
parasites

作用机制

DNA synthesis | interferes
enzyme | inhibits

SMILES字符串

COc1cc(NS(=O)(=O)c2ccc(N)cc2)ncn1

InChI

1S/C11H12N4O3S/c1-18-11-6-10(13-7-14-11)15-19(16,17)9-4-2-8(12)3-5-9/h2-7H,12H2,1H3,(H,13,14,15)

InChI key

WMPXPUYPYQKQCX-UHFFFAOYSA-N

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相关类别

一般描述

化学结构：磺胺

应用

磺胺间甲氧嘧啶是一种长效磺胺类抗菌药。用于研究 Fe 3 O 4 磁性纳米颗粒的降解 。用于血液动力学研究，并用于研究 支气管炎博德特菌的荚膜形成 。

生化/生理作用

磺胺间甲氧嘧啶是二氢喋呤合成酶的竞争性抑制剂，用于阻断叶酸的合成。

其他说明

保存于密闭容器内，置于干燥通风处。

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Thomas Trolle et al.
Bioinformatics (Oxford, England), 31(13), 2174-2181 (2015-02-27)
Numerous in silico methods predicting peptide binding to major histocompatibility complex (MHC) class I molecules have been developed over the last decades. However, the multitude of available prediction tools makes it non-trivial for the end-user to select which tool to
C Girardi et al.
Pharmacological research, 22(2), 79-86 (1990-03-01)
Intrauterine administration was performed in six Friesan cows with a disposable spray preparation containing 3 g of sulfamonomethoxine and 3 g of oxytetracycline, in order to investigate their serum kinetics. Sulfamonomethoxine levels were determined by a reversed-phase HPLC method, whilst
A Kuwano
Zentralblatt fur Veterinarmedizin. Reihe B. Journal of veterinary medicine. Series B, 38(9), 685-688 (1991-11-01)
Bordetella bronchiseptica phase I organism possesses a capsule and has the ability to agglutinate with K antiserum, although phase III organism lacks both. The present study examines the effect of sulfamonomethoxine (SMMX) on capsule formation of B. bronchiseptica. I also
G Zhang et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 25(4), 413-423 (2008-03-19)
A rapid lateral flow immunoassay screening method has been developed for the determination of sulfamonomethoxine (SMM) residues in swine urine. For this purpose, a specific monoclonal antibody (mAb), SMM4B9 for SMM, was generated and characterized. The mAb showed low cross-reactivity
Jingchun Yan et al.
Chemosphere, 87(2), 111-117 (2011-12-24)
Ferrous hydroxide colloids were prepared and characterized as an activator of H(2)O(2) for decomposing organic pollutants, such as Rhodamine B, sulfamonomethoxine (SMM) and 4-nitrophenol (4-NP). As major reactive oxygen species, hydroxyl radicals were confirmed to be generated in the activation
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