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S0774

链霉素硫酸盐

Name: 链霉素 硫酸盐
Brand: SIGMA

suitable for plant cell culture

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关于此项目

线性分子式:

C₂₁H₃₉N₇O₁₂ · 1.5 H₂SO₄

化学文摘社编号:

3810-74-0

分子量:

728.69

EC Number:

223-286-0

UNSPSC Code:

51101500

PubChem Substance ID:

24899445

Beilstein/REAXYS Number:

3894995

MDL number:

MFCD00037023

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form

powder

potency

≥720 μg per mg

storage condition

(Keep container tightly closed in a dry and well-ventilated place.)

technique(s)

cell culture | plant: suitable

color

white to off-white

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

protein synthesis | interferes

storage temp.

2-8°C

SMILES string

OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@H]2[C@@H](O[C@@H](C)[C@]2(O)C=O)O[C@@H]3[C@@H](O)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]3NC(N)=N.CN[C@H]4[C@H](O)[C@@H](O)[C@H](CO)O[C@H]4O[C@H]5[C@@H](O[C@@H](C)[C@]5(O)C=O)O[C@@H]6[C@@H](O)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]6NC(N)=N

InChI

1S/2C21H39N7O12.3H2O4S/c2*1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35;3*1-5(2,3)4/h2*4-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28);3*(H2,1,2,3,4)/t2*5-,6-,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,21+;;;/m00.../s1

InChI key

QTENRWWVYAAPBI-YZTFXSNBSA-N

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General description

Chemical structure: aminoglycoside

Application

Used together with penicillin and other agents to inhibit bacterial contamination in cell culture applications.

Biochem/physiol Actions

作用机制：链霉素可通过与30S核糖体亚基的S12蛋白结合而抑制原核生物蛋白的合成，从而阻止了从模拟复合物向链延长核糖体的转变。这会导致编码错误或抑制启动。

耐药性机制：rpsL这种S12核糖体蛋白基因中的突变可阻止链霉素与核糖体结合。一种氨基糖苷磷酸转移酶也可使链霉素失活。

抗菌谱：链霉素能够对抗革兰氏阴性和革兰氏阳性菌。

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

pictograms

GHS08,GHS07

signalword

Warning

hcodes

H302,H361fd

pcodes

P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

涉药品监管产品

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