S101
(R)-(+)-SKF-38393 盐酸盐
≥98% (HPLC), solid
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关于此项目
经验公式（希尔记法）:
C16H17NO2 · HCl
化学文摘社编号:
分子量:
291.77
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
(R)-(+)-SKF-38393 盐酸盐, ≥98% (HPLC), solid
InChI
1S/C16H17NO2.ClH/c18-15-8-12-6-7-17-10-14(13(12)9-16(15)19)11-4-2-1-3-5-11;/h1-5,8-9,14,17-19H,6-7,10H2;1H/t14-;/m1./s1
SMILES string
Cl.Oc1cc2CCNC[C@H](c3ccccc3)c2cc1O
InChI key
YEWHJCLOUYPAOH-PFEQFJNWSA-N
assay
≥98% (HPLC)
form
solid
optical activity
[α]22/D +16.1°, c = 1.2 in methanol(lit.)
storage condition
desiccated
color
off-white to light tan
solubility
0.1 M HCl: 1.2 mg/mL
ethanol: 3.4 mg/mL
H2O: 5 mg/mL
aqueous base: unstable
Quality Level
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相关类别
Application
(R)-(+)-SKF-38393盐酸盐已用作D1多巴胺受体激动剂，研究其对1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP)诱导帕金森病猕猴睡眠模式的影响。
Biochem/physiol Actions
(R)-(+)-SKF-38393盐酸盐是一种D1多巴胺受体激动剂和(±)-SKF-38393的活性对映异构体。它可增强海马体神经元中百日咳毒素不敏感性和蛋白激酶A介导谷氨酸释放。SKF-38393是一种苯并氮杂卓衍生物，具有降低食欲的作用。
Disclaimer
光敏感
Preparation Note
溶液可在4°C条件下储存数日。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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