S1068
SB-215505
solid, >98% (HPLC)
别名:
6-Chloro-5-methyl-1-5-quinolycarbamoyl-indoline
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关于此项目
经验公式（希尔记法）:
C19H16N3OCl
化学文摘社编号:
分子量:
337.80
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI key
BPVGSWDWIRIUME-UHFFFAOYSA-N
SMILES string
Cc1cc2CCN(C(=O)Nc3ccnc4ccccc34)c2cc1Cl
InChI
1S/C19H16ClN3O/c1-12-10-13-7-9-23(18(13)11-15(12)20)19(24)22-17-6-8-21-16-5-3-2-4-14(16)17/h2-6,8,10-11H,7,9H2,1H3,(H,21,22,24)
assay
>98% (HPLC)
form
solid
color
off-white
solubility
DMSO: soluble ~11 mg/mL at 60 °C, H2O: insoluble
originator
GlaxoSmithKline
storage temp.
2-8°C
Gene Information
human ... HTR2B(3357)
Biochem/physiol Actions
Selective 5-HT2B serotonin receptor antagonist; 100-fold higher affinity at 2B versus 2C.
Features and Benefits
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Legal Information
Sold for research purposes under agreement from GlaxoSmithKline
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Adam J Isabella et al.
Developmental cell, 53(3), 344-357 (2020-04-18)
Information flow through neural circuits often requires their organization into topographic maps in which the positions of cell bodies and synaptic targets correspond. To understand how topographic map development is controlled, we examine the mechanism underlying targeting of vagus motor
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