S1318
STO-609-乙酸
≥95% (HPLC), solid
别名:
7-Oxo-7H-苯并咪唑并[2,1-a]苯并[de]异喹啉-3-羧酸-乙酸
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选择尺寸
关于此项目
经验公式（希尔记法）:
C19H10N2O3 · C2H4O2
化学文摘社编号:
分子量:
374.35
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352106
MDL number:
产品名称
STO-609-乙酸, ≥95% (HPLC), solid
InChI
1S/C19H10N2O3.C2H4O2/c22-18-13-5-3-4-10-11(19(23)24)8-9-12(16(10)13)17-20-14-6-1-2-7-15(14)21(17)18;1-2(3)4/h1-9H,(H,23,24);1H3,(H,3,4)
SMILES string
CC(O)=O.OC(=O)c1ccc2-c3nc4ccccc4n3C(=O)c5cccc1c25
InChI key
WNRSTFUVBWNELX-UHFFFAOYSA-N
assay
≥95% (HPLC)
form
solid
mp
>300 °C
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
2-8°C
Quality Level
相关类别
Application
STO609已被用作小鼠MLL-AF9急性髓系细胞白血病 (AML) 细胞中的钙/钙钙调蛋白依赖性蛋白激酶的激酶(CAMKK)抑制剂。
Biochem/physiol Actions
选择性 Ca2+/钙调蛋白依赖性蛋白激酶的激酶 (CaM-KK) 拮抗剂。
选择性Ca2+/钙调蛋白依赖性蛋白激酶的激酶 (CaM-KK) 拮抗剂。分别抑制 Ki = 80 和 15 ng/mL 的 CamKKa 和 CaMKKb。不抑制下游 CaM 激酶（CaMKI 和 CaMKIV）。
General description
STO-609可降低体内肝癌细胞的致瘤性。TO-609以剂量依赖性方式减少了离子霉素对AMP（单磷酸腺苷）激活的蛋白激酶(AMPK)的激活。
乙酸1:1加合物
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
CAMKs support development of acute myeloid leukemia
Kang X, et al.
Journal of Hematology & Oncology, 11(1), 30-30 (2018)
The camKK2/camKIV relay is an essential regulator of hepatic cancer
Lin F, et al.
Hepatology, 62(2), 505-520 (2015)
Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells
Woods A, et al.
Cell Metabolism, 2(1), 21-33 (2005)
Liping Shen et al.
Toxicology, 421, 22-29 (2019-04-04)
Voltage-gated sodium channels (VGSCs) represent molecular targets for a number of potent neurotoxins that affect the ion permeation or gating kinetics. BmK NT1, an α-scorpion toxin purified from Buthus martensii Karch (BMK), induces excitatory neurotoxicity by activation of VGSCs with
Weiwei Shi et al.
Molecular and cellular biochemistry, 449(1-2), 219-226 (2018-04-21)
Autosomal dominant polycystic kidney disease (ADPKD) is a common heritable human disease. Recently, the role of repressed autophagy in ADPKD has drawn increasing attention. Here, we investigate the mechanism underlying the effect of Saikosaponin-d (SSd), a sarcoplasmic/endoplasmic reticulum Ca2+ ATPase
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