S143
(±)-6-Chloro-PB hydrobromide
≥98% (HPLC), D1 dopamine receptor agonist, solid
别名:
(±)-6-Chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide, (±)-SKF-81297 hydrobromide
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C16H16ClNO2 · HBr
化学文摘社编号:
分子量:
370.67
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
(±)-6-Chloro-PB hydrobromide, ≥98% (HPLC), solid
SMILES string
Br[H].Oc1cc2C(CNCCc2c(Cl)c1O)c3ccccc3
InChI
1S/C16H16ClNO2.BrH/c17-15-11-6-7-18-9-13(10-4-2-1-3-5-10)12(11)8-14(19)16(15)20;/h1-5,8,13,18-20H,6-7,9H2;1H
InChI key
RMIJGBMRNYUZRG-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
storage condition
desiccated
color
white to light tan
solubility
H2O: 1.7 mg/mL
DMSO: >10 mg/mL
ethanol: 6.3 mg/mL
Quality Level
Gene Information
human ... DRD1(1812)
正在寻找类似产品? 访问 产品对比指南
Application
(±)-6-Chloro-PB hydrobromide has been used as a dopamine D1 receptor (Drd1a) agonist to study the role of the drd1a-dopamine receptor inactivation of extracellular signal‑regulated protein kinase 1/2 (ERK1/2) in the wild-type and striatum of dopamine-depleted mice. It has also been used as a Drd1a agonist to identify the contribution of D1 (D1R)-like dopamine receptor signaling on learning and memory in Barnes maze in rats.
Biochem/physiol Actions
(+/-)-6-Chloro-PB HBr is a full D1 dopamine receptor agonist.
Disclaimer
Product is air and light sensitive
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
K Kawamoto et al.
British journal of pharmacology, 166(2), 788-800 (2011-12-16)
Dopamine released from the endings of descending dopaminergic nerve fibres in the spinal cord may be involved in modulating functions such as locomotion and nociception. Here, we examined the effects of dopamine on spinal synaptic transmissions in rats. Spinal reflex
P A Johansen et al.
Journal of neural transmission. General section, 86(2), 97-113 (1991-01-01)
The electrophysiological effects of three selective D1 dopamine (DA) receptor agonists, which exhibit different potencies and efficacies for stimulation of adenylate cyclase, were compared in the rat nucleus accumbens (NAc) using single unit recording and microiontophoretic techniques. The partial agonists
Charles R Gerfen et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 28(28), 7113-7120 (2008-07-11)
Dopamine receptor signaling exhibits prominent plasticity that is important for the pathogenesis of both addictive and movement disorders. Psychoactive stimulants that activate the dopamine D(1) receptor (Drd1a) induce the rapid phosphorylation and activation of extracellular signal-regulated kinase 1/2 (ERK1/2) in
Giuseppe Gangarossa et al.
Brain structure & function, 218(2), 405-419 (2012-03-29)
Therapeutic agents and drugs of abuse regulate the extracellular signal-regulated kinase (ERK) cascade signaling in the medium-sized spiny neurons (MSNs) of the striatum. However, whether this regulation is associated with specific cortical and thalamic inputs has never been studied. We
A M Knab et al.
Journal of biological regulators and homeostatic agents, 26(1), 119-129 (2012-04-06)
The genetic factors involved in the regulation of physical activity are not well understood. The dopamine system has been implicated in the control of voluntary locomotion and wheel running (WR) in mice and is thus a likely candidate as a
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持