S143
(±)-6-Chloro-PB hydrobromide
≥98% (HPLC), D1 dopamine receptor agonist, solid
别名:
(±)-6-Chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide, (±)-SKF-81297 hydrobromide
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关于此项目
经验公式（希尔记法）:
C16H16ClNO2 · HBr
化学文摘社编号:
分子量:
370.67
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
(±)-6-Chloro-PB hydrobromide, ≥98% (HPLC), solid
质量水平
方案
≥98% (HPLC)
表单
solid
储存条件
desiccated
颜色
white to light tan
溶解性
H2O: 1.7 mg/mL
DMSO: >10 mg/mL
ethanol: 6.3 mg/mL
SMILES字符串
Br[H].Oc1cc2C(CNCCc2c(Cl)c1O)c3ccccc3
InChI
1S/C16H16ClNO2.BrH/c17-15-11-6-7-18-9-13(10-4-2-1-3-5-10)12(11)8-14(19)16(15)20;/h1-5,8,13,18-20H,6-7,9H2;1H
InChI key
RMIJGBMRNYUZRG-UHFFFAOYSA-N
基因信息
human ... DRD1(1812)
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应用
(±)-6-Chloro-PB hydrobromide has been used as a dopamine D1 receptor (Drd1a) agonist to study the role of the drd1a-dopamine receptor inactivation of extracellular signal‑regulated protein kinase 1/2 (ERK1/2) in the wild-type and striatum of dopamine-depleted mice. It has also been used as a Drd1a agonist to identify the contribution of D1 (D1R)-like dopamine receptor signaling on learning and memory in Barnes maze in rats.
生化/生理作用
(+/-)-6-Chloro-PB HBr is a full D1 dopamine receptor agonist.
免责声明
Product is air and light sensitive
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
A M Knab et al.
Journal of biological regulators and homeostatic agents, 26(1), 119-129 (2012-04-06)
The genetic factors involved in the regulation of physical activity are not well understood. The dopamine system has been implicated in the control of voluntary locomotion and wheel running (WR) in mice and is thus a likely candidate as a
K Kawamoto et al.
British journal of pharmacology, 166(2), 788-800 (2011-12-16)
Dopamine released from the endings of descending dopaminergic nerve fibres in the spinal cord may be involved in modulating functions such as locomotion and nociception. Here, we examined the effects of dopamine on spinal synaptic transmissions in rats. Spinal reflex
Giuseppe Gangarossa et al.
Brain structure & function, 218(2), 405-419 (2012-03-29)
Therapeutic agents and drugs of abuse regulate the extracellular signal-regulated kinase (ERK) cascade signaling in the medium-sized spiny neurons (MSNs) of the striatum. However, whether this regulation is associated with specific cortical and thalamic inputs has never been studied. We
Charles R Gerfen et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 28(28), 7113-7120 (2008-07-11)
Dopamine receptor signaling exhibits prominent plasticity that is important for the pathogenesis of both addictive and movement disorders. Psychoactive stimulants that activate the dopamine D(1) receptor (Drd1a) induce the rapid phosphorylation and activation of extracellular signal-regulated kinase 1/2 (ERK1/2) in
P A Johansen et al.
Journal of neural transmission. General section, 86(2), 97-113 (1991-01-01)
The electrophysiological effects of three selective D1 dopamine (DA) receptor agonists, which exhibit different potencies and efficacies for stimulation of adenylate cyclase, were compared in the rat nucleus accumbens (NAc) using single unit recording and microiontophoretic techniques. The partial agonists
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