S180
SB-206553 hydrochloride hydrate
≥98% (HPLC), solid
别名:
5-Methyl-1-(3-pyridylcarbamoyl)-1,2,3,5-tetrahydropyrrolo[2,3-f]indole hydrochloride hydrate, N-3-Pyridinyl-3,5-dihydro-5-methylbenzo(1,2-b:4,5-b′)dipyrrole-1(2H)carboxamide hydrochloride hydrate
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关于此项目
经验公式（希尔记法）:
C17H16N4O · HCl · xH2O
化学文摘社编号:
分子量:
328.80 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C17H16N4O.ClH.H2O/c1-20-7-4-12-10-16-13(9-15(12)20)5-8-21(16)17(22)19-14-3-2-6-18-11-14;;/h2-4,6-7,9-11H,5,8H2,1H3,(H,19,22);1H;1H2
SMILES string
O.Cl.Cn1ccc2cc3N(CCc3cc12)C(=O)Nc4cccnc4
InChI key
NXGFRKQJHLVHIT-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
color
yellow
solubility
H2O: >10 mg/mL
Gene Information
human ... HTR2B(3357), HTR2C(3358)
Application
SB-206553 hydrochloride hydrate has been used as a serotonin type 2B/2C receptor (5HT2B/2CR) blocker to study its effects on sheep mitral valves.
Biochem/physiol Actions
SB-206553 is a serotonin type 2B/2C receptor (5HT2B/2CR) antagonist.
Legal Information
Manufactured and sold under exclusive license from GlaxoSmithKline Pharmaceuticals
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
M J Millan et al.
Neuropharmacology, 36(4-5), 743-745 (1997-04-01)
The 5-HT1A receptor agonist, 8-OH-DPAT ((+/-)-8-dihydroxy-2-(di-n-propylamino) tetralin), (0.63 mg/kg, s.c.) elicited spontaneous tail-flicks (STFs) in rats. This response was potentiated by the selective 5-HT2C receptor agonist, RO 60-0175 ((S)-2-(6-chloro-5-fluoroindol-1-yl)-1-methylethylamine) fumarate) (0.16 mg/kg, s.c.), the action of which was abolished by
Hadas Shatz-Azoulay et al.
Scientific reports, 10(1), 7375-7375 (2020-05-02)
Secreted animal lectins of the galectin family are key players in cancer growth and metastasis. Here we show that galectin-8 (gal-8) induces the expression and secretion of cytokines and chemokines such as SDF-1 and MCP-1 in a number of cell
I T Forbes et al.
Journal of medicinal chemistry, 39(25), 4966-4977 (1996-12-06)
The synthesis and biological activity are reported for a series of analogues of the previously published indole urea 2 (SB-206553), designed to probe the 5-HT(2C) receptor binding site. Small molecule modeling studies have been used to define a region in
R T Jensen et al.
Pharmacological reviews, 60(1), 1-42 (2007-12-07)
The mammalian bombesin receptor family comprises three G protein-coupled heptahelical receptors: the neuromedin B (NMB) receptor (BB(1)), the gastrin-releasing peptide (GRP) receptor (BB(2)), and the orphan receptor bombesin receptor subtype 3 (BRS-3) (BB(3)). Each receptor is widely distributed, especially in
O Yoshie et al.
Journal of biochemistry, 100(3), 531-541 (1986-09-01)
Highly purified recombinant human tumor necrosis factor (TNF) (molecular mass determined as 17 kilodaltons (kDa) by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and as 36 kDa by Sephadex G-100 gel chromatography) was labeled with 125I to a specific activity of 5
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