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S3066

SKF-89626 hydrobromide

>98% (HPLC), solid

别名:

4-(3,4-Dihydroxyphenyl)-4,5,6,7-tetrahydro­thieno[2,3-c]pyridine

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关于此项目

经验公式（希尔记法）:
C13H13NO2S · HBr
分子量:
328.22
UNSPSC Code:
12352200
PubChem Substance ID:
24278702
MDL number:
MFCD04040024
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assay

>98% (HPLC)

form

solid

color

white

solubility

H2O: soluble 11 mg/mL

SMILES string

Br[H].Oc1ccc(cc1O)C2CNCc3sccc23

InChI

1S/C13H13NO2S.BrH/c15-11-2-1-8(5-12(11)16)10-6-14-7-13-9(10)3-4-17-13;/h1-5,10,14-16H,6-7H2;1H

InChI key

QAIGGSDECIJPNW-UHFFFAOYSA-N

Gene Information

human ... DRD1(1812)

Application

SKF-89626 hydrobromide may be used in dopaminergic cell signaling studies.

Biochem/physiol Actions

D1 dopamine receptor agonist.
SKF-89626 is an isoquinoline derivative that fully antagonizes dopamine D1 receptor and stimulates adenylate cyclase and modulates dopaminergic-mediated cell responses.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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分析证书(COA)

Lot/Batch Number
032K4707

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E B Nielsen et al.
European journal of pharmacology, 160(2), 253-262 (1989-01-31)
Dopamine (DA) D-1 and D-2 receptor agonists and antagonists were characterized in receptor binding and adenylate cyclase assays with respect to affinity, selectivity and efficacy. The ability of the ligands to interact with the discriminative stimulus effects of d-amphetamine (AMPH)
P H Andersen et al.
European journal of pharmacology, 188(6), 335-347 (1990-06-12)
Dopamine receptor selectivity was investigated for a number of dopamine receptor agonists. In vitro, the benzazepine derivatives, e.g., SKF 38393 and SKF 75670 as well as the isoquinoline derivatives, SKF 89626 and SKF 89615, were D1 receptor-selective. All other compounds