S3573
Anti-SPHK2 (696-710) antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
别名:
Anti-sphingosine kinase 2
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
4
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~69 kDa
species reactivity
human
technique(s)
western blot: 1:500-1:2,000
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... SPHK2(56848)
General description
SPHK (sphingosine kinase) has two isoforms, namely SPHK1 and SPHK2 (sphingosine kinase 1 and 2). SPHK2 is abundantly expressed in liver, kidney, brain and heart. It is located on chromosome 19q13.
Immunogen
synthetic peptide corresponding to amino acids 696-710 of human SPHK2.
Application
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit
sigma.com/htcb-if.
sigma.com/htcb-if.
Biochem/physiol Actions
SPHK2 (sphingosine kinase 2) induces the invasion and multiplication of colorectal cancer cell by increasing the expression of MYC (protooncogene). Reactions of all-trans-retinoic acid (ATRA) on colon cancer cells enhances due to improper expression of SphK2.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
Down-regulation of sphingosine kinase 2 (SphK2) increases the effects of all-trans-retinoic acid (ATRA) on colon cancer cells
Chu JH, et al.
Biomedicine and Pharmacotherapy, 68(8), 1089-1097 (2014)
Comparison of human chromosome 19q13 and syntenic region on mouse chromosome 7 reveals absence, in man, of 11.6 Mb containing four mouse calcium-sensing receptor-related sequences: relevance to familial benign hypocalciuric hypercalcaemia type 3
Hannan FM, et al.
European Journal of Human Genetics, 18(4), 442-447 (2010)
Sphingosine kinase 2 promotes colorectal cancer cell proliferation and invasion by enhancing MYC expression
Zhang L, et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 37(6), 8455-8460 (2016)
Targeting sphingosine kinase 2 (SphK2) by ABC294640 inhibits colorectal cancer cell growth in vitro and in vivo
Xun C, et al.
Journal of Experimental & Clinical Cancer Research, 34 (2015)
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