生物来源
rabbit
偶联物
unconjugated
抗体形式
IgG fraction of antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen ~69 kDa
种属反应性
human
技术
western blot: 1:500-1:2,000
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... SPHK2(56848)
一般描述
SPHK (sphingosine kinase) has two isoforms, namely SPHK1 and SPHK2 (sphingosine kinase 1 and 2). SPHK2 is abundantly expressed in liver, kidney, brain and heart. It is located on chromosome 19q13.
免疫原
synthetic peptide corresponding to amino acids 696-710 of human SPHK2.
应用
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit
sigma.com/htcb-if.
sigma.com/htcb-if.
生化/生理作用
SPHK2 (sphingosine kinase 2) induces the invasion and multiplication of colorectal cancer cell by increasing the expression of MYC (protooncogene). Reactions of all-trans-retinoic acid (ATRA) on colon cancer cells enhances due to improper expression of SphK2.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
未找到合适的产品？
试试我们的产品选型工具.
储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
Targeting sphingosine kinase 2 (SphK2) by ABC294640 inhibits colorectal cancer cell growth in vitro and in vivo
Xun C, et al.
Journal of Experimental & Clinical Cancer Research, 34 (2015)
Sphingosine kinase 2 promotes colorectal cancer cell proliferation and invasion by enhancing MYC expression
Zhang L, et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 37(6), 8455-8460 (2016)
Comparison of human chromosome 19q13 and syntenic region on mouse chromosome 7 reveals absence, in man, of 11.6 Mb containing four mouse calcium-sensing receptor-related sequences: relevance to familial benign hypocalciuric hypercalcaemia type 3
Hannan FM, et al.
European Journal of Human Genetics, 18(4), 442-447 (2010)
Down-regulation of sphingosine kinase 2 (SphK2) increases the effects of all-trans-retinoic acid (ATRA) on colon cancer cells
Chu JH, et al.
Biomedicine and Pharmacotherapy, 68(8), 1089-1097 (2014)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持