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Merck
CN

S4146

Sigma-Aldrich

Sarafotoxin S6b Atractaspis engaddensis sequence

≥90% (HPLC)

别名:

SRTX-b

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关于此项目

经验公式（希尔记法）:
C110H159N27O34S5
化学文摘社编号:
116303-65-2
分子量:
2563.92
MDL编号:
MFCD00153553
UNSPSC代码:
12352200
PubChem化学物质编号:
329824539

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方案

≥90% (HPLC)

储存温度

−20°C

SMILES字符串

CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]2CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@H]3CSSC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC3=O)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc4ccc(O)cc4)C(=O)N[C@@H](Cc5ccccc5)C(=O)N2)C(C)C)C(=O)N[C@@H](Cc6c[nH]c7ccccc67)C(O)=O

InChI

1S/C110H159N27O34S5/c1-9-55(6)88(108(168)130-77(110(170)171)40-59-45-116-64-22-14-13-21-62(59)64)136-107(167)87(54(4)5)135-102(162)76(44-86(148)149)128-93(153)67(29-31-82(114)141)121-99(159)73(41-60-46-115-52-117-60)126-106(166)81-49-174-173-48-63(113)90(150)131-78(47-138)103(163)134-79-50-175-176-51-80(105(165)123-70(37-53(2)3)96(156)124-72(39-58-25-27-61(140)28-26-58)97(157)125-71(98(158)133-81)38-57-19-11-10-12-20-57)132-94(154)68(30-32-83(142)143)120-91(151)65(23-15-17-34-111)118-101(161)75(43-85(146)147)129-109(169)89(56(7)139)137-95(155)69(33-36-172-8)122-100(160)74(42-84(144)145)127-92(152)66(119-104(79)164)24-16-18-35-112/h10-14,19-22,25-28,45-46,52-56,63,65-81,87-89,116,138-140H,9,15-18,23-24,29-44,47-51,111-113H2,1-8H3,(H2,114,141)(H,115,117)(H,118,161)(H,119,164)(H,120,151)(H,121,159)(H,122,160)(H,123,165)(H,124,156)(H,125,157)(H,126,166)(H,127,152)(H,128,153)(H,129,169)(H,130,168)(H,131,150)(H,132,154)(H,133,158)(H,134,163)(H,135,162)(H,136,167)(H,137,155)(H,142,143)(H,144,145)(H,146,147)(H,148,149)(H,170,171)/t55-,56+,63-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,87-,88-,89-/m0/s1

InChI key

ZHRYDGYRZIWZPS-RAALVGGVSA-N

Amino Acid Sequence

Cys-Ser-Cys-Lys-Asp-Met-Thr-Asp-Lys-Glu-Cys-Leu-Tyr-Phe-Cys-His-Gln-Asp-Val-Ile-Trp [Disulfide Bridges: 1-15, 3-11]

生化/生理作用

ETA agonist; increases intracellular Ca2+

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

高风险级别生物产品--毒素类产品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
109F05913
072H01201
105K1296
089H1302
072H01202

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A Bagnato et al.
British journal of pharmacology, 163(2), 220-233 (2011-01-15)
The endothelins (ET) are a group of proteins that act through G-protein coupled receptors. Endothelin-1 (ET-1) was initially identified as a potent vasoconstrictor and dysregulation of the ET axis contributes to pathological processes responsible for cardiovascular disease states. More recently
Travis W Hein et al.
Investigative ophthalmology & visual science, 50(7), 3329-3336 (2009-01-20)
Activation of the endothelin (ET) system has been implicated in the pathogenesis of retinal ischemic disease. Although ET-1, the predominant endogenous isoform of ET, has been shown to cause constriction of retinal vessels, the expression and functional significance of its
Endothelin increases the ciliary beat frequency of ovine airway epithelium via its interaction with endothelin a receptors.
Pawsey J, Lansley AB, Lethem MI.
Pulmonary Pharmacology, 24, 602-609 (2011)
Y Kloog et al.
Science (New York, N.Y.), 242(4876), 268-270 (1988-10-14)
Sarafotoxins, a group of 21-residue cardiotoxic peptides from snake venom that induce coronary vasoconstriction, show high-affinity binding to rat atrial and brain membranes and activate the hydrolysis of phosphoinositides. Neither their binding nor their activity is affected by blockers or
Nathan R Tykocki et al.
The Journal of pharmacology and experimental therapeutics, 329(3), 875-881 (2009-03-20)
Endothelin receptors (ET(A) and ET(B)) mediate responses to ET-1. ET(B) receptor function seems to differ between a similarly sized arterial and venous pair, the rat vena cava (RVC) and rat thoracic aorta (RA). ET(B) receptors mediate RVC contraction directly, but
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