生物来源
rabbit
偶联物
unconjugated
抗体形式
IgG fraction of antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 60 kDa
种属反应性
rat
技术
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100 using 0.5% paraformaldehyde fixed/0.5% Triton X-100 treated rat skeletal muscle
microarray: suitable
western blot: 1:1,000 using rat skeletal muscle homogenate extract (membrane fraction)
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... SNTA1(6640)
rat ... Snta1(362242)
一般描述
Syntrophins are expressed in a wide range of tissues. α1-Syntrophin (SNTA1) contain two pleckstrin (PH) homology domains, found in a wide array of signaling proteins. SNTA1 gene is located on human chromosome 20q11.2. In rat skeletal muscle, α1-syntrophins are mainly found to be located on the sarcolemma.
免疫原
synthetic peptide located at the N-terminus of human α1-syntrophin (amino acids 2-18 with C-terminally added lysine) conjugated to KLH.
应用
Anti-α1-Syntrophin (AG-17) antibody produced in rabbit may be used in immunoblotting and immunohistochemistry.
生化/生理作用
Anti-a1-Syntrophin (AG-17) recognizes a1-syntrophin (60 kDa).
Syntrophins associate with the dystrophin complex to act as modular adapters and helps in recruiting signaling proteins to the membrane. The pleckstrin (PH) homology domains of α1-Syntrophin (SNTA1) mainly helps in mediating this recruiting action. Mutation on this gene is accountable for long QT syndrome 12 (LQT12), an autosomal-dominant manner.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide
制备说明
For continuous use, store at 2 °C - 8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. Storage in "frost-free" freezers is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
The smallest de novo 20q11. 2 microdeletion causing intellectual disability and dysmorphic features
Hanafusa H, et al.
Human Genome Variation, 4, 1-4 (2017)
Differential association of syntrophin pairs with the dystrophin complex
Peters MF, et al.
The Journal of Cell Biology, 138, 81-93 (1997)
Dávid Szöllősi et al.
Neuropathology : official journal of the Japanese Society of Neuropathology, 38(3), 207-217 (2017-12-22)
The frequency of cerebrovascular injuries raises the importance of their immunohistological investigation in postmortem materials. Most injuries involve the impairment of the blood-brain barrier. The barrier is maintained by the glio-vascular connections which break up following injuries. Some immunohistochemical alterations
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