S4688
Anti-α1-Syntrophin (AG-17) antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
别名:
Anti-SNTA1
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关于此项目
UNSPSC Code:
12352203
MDL number:
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ARR, IHC (p), WB
Citations:
3
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 60 kDa
species reactivity
rat
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100 using 0.5% paraformaldehyde fixed/0.5% Triton X-100 treated rat skeletal muscle, microarray: suitable, western blot: 1:1,000 using rat skeletal muscle homogenate extract (membrane fraction)
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... SNTA1(6640)
rat ... Snta1(362242)
General description
Syntrophins are expressed in a wide range of tissues. α1-Syntrophin (SNTA1) contain two pleckstrin (PH) homology domains, found in a wide array of signaling proteins. SNTA1 gene is located on human chromosome 20q11.2. In rat skeletal muscle, α1-syntrophins are mainly found to be located on the sarcolemma.
Immunogen
synthetic peptide located at the N-terminus of human α1-syntrophin (amino acids 2-18 with C-terminally added lysine) conjugated to KLH.
Application
Anti-α1-Syntrophin (AG-17) antibody produced in rabbit may be used in immunoblotting and immunohistochemistry.
Biochem/physiol Actions
Anti-a1-Syntrophin (AG-17) recognizes a1-syntrophin (60 kDa).
Syntrophins associate with the dystrophin complex to act as modular adapters and helps in recruiting signaling proteins to the membrane. The pleckstrin (PH) homology domains of α1-Syntrophin (SNTA1) mainly helps in mediating this recruiting action. Mutation on this gene is accountable for long QT syndrome 12 (LQT12), an autosomal-dominant manner.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide
Preparation Note
For continuous use, store at 2 °C - 8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. Storage in "frost-free" freezers is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
The smallest de novo 20q11. 2 microdeletion causing intellectual disability and dysmorphic features
Hanafusa H, et al.
Human Genome Variation, 4, 1-4 (2017)
Differential association of syntrophin pairs with the dystrophin complex
Peters MF, et al.
The Journal of Cell Biology, 138, 81-93 (1997)
Dávid Szöllősi et al.
Neuropathology : official journal of the Japanese Society of Neuropathology, 38(3), 207-217 (2017-12-22)
The frequency of cerebrovascular injuries raises the importance of their immunohistological investigation in postmortem materials. Most injuries involve the impairment of the blood-brain barrier. The barrier is maintained by the glio-vascular connections which break up following injuries. Some immunohistochemical alterations
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