生物来源
mouse
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
SN43, monoclonal
表单
buffered aqueous solution
分子量
antigen ~52 kDa
种属反应性
human
浓度
~2.0 mg/mL
技术
immunocytochemistry: suitable
indirect ELISA: suitable
western blot: 2-4 μg/mL using total cell extract of SNX4-GFP transfected HEK-293T cells
同位素/亚型
IgG1
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... SNX4(8723)
一般描述
Monoclonal Anti-SNX4 (mouse IgG1 isotype) is derived from the hybridoma SN43 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide. Sorting Nexins 4 (SNX4) protein belongs to the sorting nexins (SNX) family. This protein contains an SNX pho homology (PX) domain (SNX-PX) and a Bin/Amphiphysin/Rvs (BAR) domain. The SNX4 gene is located on the human chromosome at 3q21.2.
免疫原
Synthetic peptide corresponding to amino acids 7-24 of human SNX4.
应用
Monoclonal Anti-SNX4 antibody produced in mouse may be used in:
- immunoblotting
- immunocytochemistry
- enzyme-linked immunosorbent assay (ELISA)
生化/生理作用
Monoclonal Anti-SNX4 reacts specifically with human SNX4.
Sorting Nexins 4 (SNX4) protein interacts with various tyrosine kinase receptors. SNX4 protein and amphiphysin 2 interact in the cell cytosol and on cytoplasmic vesicular structures. Overexpression of the SNX4 gene blocks the endocytosis of the transferrin receptor as efficiently as amphiphysin 2. The SNX4/amphiphysin 2 complex is essential for the control of the endosome fate after the formation of the endocytic vesicle.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
制备说明
For extended storage, freeze at -20 °C in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discard if not used within 12 hours.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
R D Teasdale et al.
The Biochemical journal, 358(Pt 1), 7-16 (2001-08-04)
Sorting nexin 1 (SNX1), a peripheral membrane protein, has previously been shown to regulate the cell-surface expression of the human epidermal growth factor receptor [Kurten, Cadena and Gill (1996) Science 272, 1008-1010]. Searches of human expressed sequence tag databases with
Jez Carlton et al.
Traffic (Copenhagen, Denmark), 6(2), 75-82 (2005-01-07)
The sorting nexins (SNXs) are a family of PX domain-containing proteins found in yeast and mammalian cells that have been proposed to regulate intracellular trafficking. Mammalian SNXs have been suggested to function variously in pro-degradative sorting, internalization, endosomal recycling, or
Dheeraj Malhotra et al.
Neuron, 72(6), 951-963 (2011-12-27)
While it is known that rare copy-number variants (CNVs) contribute to risk for some neuropsychiatric disorders, the role of CNVs in bipolar disorder is unclear. Here, we reasoned that a contribution of CNVs to mood disorders might be most evident
Corinne Leprince et al.
Journal of cell science, 116(Pt 10), 1937-1948 (2003-04-02)
Endocytosis is a regulated physiological process by which membrane receptors and their extracellular ligands are internalized. After internalization, they enter the endosomal trafficking pathway for sorting and processing. Amphiphysins consist of a family of proteins conserved throughout evolution that are
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