S5317
SKF-95282 dimaleate salt
solid, >98% (HPLC)
别名:
N-[3-[3-(1-Piperidinylmethyl)phenoxy]propyl]-2-benzothiazolamine, Zolantidine
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关于此项目
经验公式（希尔记法）:
C22H27N3OS · 2C4H4O4
化学文摘社编号:
分子量:
613.68
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
InChI
1S/C22H27N3OS.2C4H4O4/c1-4-13-25(14-5-1)17-18-8-6-9-19(16-18)26-15-7-12-23-22-24-20-10-2-3-11-21(20)27-22;2*5-3(6)1-2-4(7)8/h2-3,6,8-11,16H,1,4-5,7,12-15,17H2,(H,23,24);2*1-2H,(H,5,6)(H,7,8)/b;2*2-1-
SMILES string
[H]\C(=C(/[H])C(O)=O)C(O)=O.[H]\C(=C(/[H])C(O)=O)C(O)=O.C1CCN(CC1)Cc2cccc(OCCCNc3nc4ccccc4s3)c2
InChI key
IECBEVAUEBZJCF-SPIKMXEPSA-N
assay
>98% (HPLC)
form
solid
color
white
solubility
H2O: soluble >10 mg/mL
storage temp.
2-8°C
Gene Information
human ... HRH2(3274)
Application
SKF 95282 dimaleate salt was one of the compounds tested for ability to cross gastrointestinal tract and blood-brain barrier by permeability assays.2
Biochem/physiol Actions
H2 Histamine receptor antagonist.
SKF 95282 is a benzthiazole derivative that potently inhibits histamine H2 receptor. It crosses the blood-brain barrier and inhibits the histamine-stimulated activity of adenylate cyclase in guinea pig brain.1
Features and Benefits
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Legal Information
Sold for research purposes under agreement from GlaxoSmithKline
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
C R Calcutt et al.
British journal of pharmacology, 93(1), 69-78 (1988-01-01)
1. The novel benzthiazole derivative zolantidine (SK&F 95282) is a potent antagonist of histamine at H2-receptors in guinea-pig atrium and rat uterus. Only apparent pA2 values of 7.46 and 7.26 respectively could be calculated since the slopes of the Schild
David S Wexler et al.
Journal of biomolecular screening, 10(4), 383-390 (2005-06-21)
Solubility and permeability are intimately linked in drug absorption processes. They have, however, been traditionally assayed separately. To support this linkage, a combined solubility/permeability assay was developed for determining absorption properties of chemical entities. First, solubility is determined at 4
Johannes Kornhuber et al.
PloS one, 6(8), e23852-e23852 (2011-09-13)
We describe a hitherto unknown feature for 27 small drug-like molecules, namely functional inhibition of acid sphingomyelinase (ASM). These entities named FIASMAs (Functional Inhibitors of Acid SphingoMyelinAse), therefore, can be potentially used to treat diseases associated with enhanced activity of
Bassem Sadek et al.
Drug design, development and therapy, 10, 3879-3898 (2016-12-10)
A series of twelve novel non-imidazole-based ligands (
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