S5317
SKF-95282 dimaleate salt
solid, >98% (HPLC)
别名:
N-[3-[3-(1-Piperidinylmethyl)phenoxy]propyl]-2-benzothiazolamine, Zolantidine
登录查看公司和协议定价
选择尺寸
关于此项目
经验公式（希尔记法）:
C22H27N3OS · 2C4H4O4
化学文摘社编号:
分子量:
613.68
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
方案
>98% (HPLC)
表单
solid
颜色
white
溶解性
H2O: soluble >10 mg/mL
储存温度
2-8°C
SMILES字符串
[H]\C(=C(/[H])C(O)=O)C(O)=O.[H]\C(=C(/[H])C(O)=O)C(O)=O.C1CCN(CC1)Cc2cccc(OCCCNc3nc4ccccc4s3)c2
InChI
1S/C22H27N3OS.2C4H4O4/c1-4-13-25(14-5-1)17-18-8-6-9-19(16-18)26-15-7-12-23-22-24-20-10-2-3-11-21(20)27-22;2*5-3(6)1-2-4(7)8/h2-3,6,8-11,16H,1,4-5,7,12-15,17H2,(H,23,24);2*1-2H,(H,5,6)(H,7,8)/b;2*2-1-
InChI key
IECBEVAUEBZJCF-SPIKMXEPSA-N
基因信息
human ... HRH2(3274)
应用
SKF 95282 dimaleate salt was one of the compounds tested for ability to cross gastrointestinal tract and blood-brain barrier by permeability assays.2
生化/生理作用
H2 Histamine receptor antagonist.
SKF 95282 is a benzthiazole derivative that potently inhibits histamine H2 receptor. It crosses the blood-brain barrier and inhibits the histamine-stimulated activity of adenylate cyclase in guinea pig brain.1
特点和优势
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
法律信息
Sold for research purposes under agreement from GlaxoSmithKline
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
C R Calcutt et al.
British journal of pharmacology, 93(1), 69-78 (1988-01-01)
1. The novel benzthiazole derivative zolantidine (SK&F 95282) is a potent antagonist of histamine at H2-receptors in guinea-pig atrium and rat uterus. Only apparent pA2 values of 7.46 and 7.26 respectively could be calculated since the slopes of the Schild
David S Wexler et al.
Journal of biomolecular screening, 10(4), 383-390 (2005-06-21)
Solubility and permeability are intimately linked in drug absorption processes. They have, however, been traditionally assayed separately. To support this linkage, a combined solubility/permeability assay was developed for determining absorption properties of chemical entities. First, solubility is determined at 4
Johannes Kornhuber et al.
PloS one, 6(8), e23852-e23852 (2011-09-13)
We describe a hitherto unknown feature for 27 small drug-like molecules, namely functional inhibition of acid sphingomyelinase (ASM). These entities named FIASMAs (Functional Inhibitors of Acid SphingoMyelinAse), therefore, can be potentially used to treat diseases associated with enhanced activity of
Bassem Sadek et al.
Drug design, development and therapy, 10, 3879-3898 (2016-12-10)
A series of twelve novel non-imidazole-based ligands (
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持