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Assay:
≥80% (SDS-PAGE)
Recombinant:
expressed in baculovirus infected insect cells
Concentration:
~0.58 mg/mL protein (Bradford assay)
recombinant
expressed in baculovirus infected insect cells
assay
≥80% (SDS-PAGE)
form
buffered aqueous glycerol solution
mol wt
60 kDa
concentration
~0.58 mg/mL protein (Bradford assay)
UniProt accession no.
application(s)
cell analysis
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... SRC(6714)
General description
SRC proto-oncogene, non-receptor tyrosine kinase (SRC) belongs to the family of non-receptor tyrosine kinases. It contains an amino-terminal domain, conserved Src-homology domains (SH2 and SH3), a tyrosine kinase domain and the carboxyl-terminus. The gene encoding this protein is localized on human chromosome 20q11.23.
Application
Human Src has been used to study the kinetics of Src entrapped in a series of different sol-gel derived materials.
Biochem/physiol Actions
SRC proto-oncogene, non-receptor tyrosine kinase (SRC) phosphorylates membrane proteins and nucleoproteins and activates various intracellular signaling cascades. It has been associated with a number of human malignancies and cancers.
Physical form
Solution in 50 mM Tris pH 7.5, 0.05 mM EDTA, 1 mM DTT, 100 mM NaCl, 0.05% NP-40, and 50% glycerol.
Other Notes
One unit will phosphorylate one nmole of poly(Gly:Tyr) 4:1 per minute at pH 7.5 at 30°C.
存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
The Tyrosine Kinase c-Src Specifically Binds to the Active Integrin aIIb?3 to Initiate Outside-in Signaling in Platelets.
Wu Y
The Journal of Biological Chemistry (2015)
Subcellular and Dynamic Coordination between Src Activity and Cell Protrusion in Microenvironment.
Zhuo Y
Scientific Reports (2015)
T R Lee et al.
The Journal of biological chemistry, 270(10), 5375-5380 (1995-03-10)
We report the first active site substrate specificity analysis of a tyrosine-specific protein kinase, namely pp60c-src. Like the cAMP-dependent protein kinase and protein kinase C, pp60c-src will phosphorylate an assortment of achiral residues attached to active site-directed peptides. Furthermore, pp60c-src
Genomic imbalances in Schistosoma-associated and non-Schistosoma-associated bladder carcinoma. An array comparative genomic hybridization analysis.
Armengol G
Cancer Genetics and Cytogenetics (2007)
Ying Zhou et al.
Journal of the American Chemical Society, 136(40), 14031-14038 (2014-09-05)
Transcriptional activation of σ(54)-RNA polymerase holoenzyme (σ(54)-RNAP) in bacteria is dependent on a cis-acting DNA element (bacterial enhancer), which recruits the bacterial enhancer-binding protein to contact the holoenzyme via DNA looping. Using a constructive synthetic biology approach, we recapitulated such
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