S5637
磺胺二甲基嘧啶 钠盐
≥98%
别名:
4-氨基-N-(4,6-二甲基-2-嘧啶基)苯磺酰胺
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关于此项目
线性分子式:
C12H13N4O2SNa
化学文摘社编号:
分子量:
300.31
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
51284910
EC Number:
217-840-0
MDL number:
产品名称
磺胺二甲基嘧啶 钠盐, ≥98%
form
powder
InChI key
WIVZAHIZHZEEOX-UHFFFAOYSA-N
InChI
1S/C12H14N4O2S.Na.H/c1-8-7-9(2)15-12(14-8)16-19(17,18)11-5-3-10(13)4-6-11;;/h3-7H,13H2,1-2H3,(H,14,15,16);;
SMILES string
[Na].Cc1cc(C)nc(NS(=O)(=O)c2ccc(N)cc2)n1
assay
≥98%
storage condition
(Keep container tightly closed in a dry and well-ventilated place.)
color
white to off-white
solubility
H2O: soluble 50 mg/mL
antibiotic activity spectrum
Gram-negative bacteria
Gram-positive bacteria
mode of action
DNA synthesis | interferes
enzyme | inhibits
storage temp.
2-8°C
Quality Level
Application
磺胺二甲嘧啶是一种抗生素，在临床上用于治疗支气管炎、前列腺炎和尿路感染。用于处置和消除动力学研究。其用于开发液体（如牛奶、蜂蜜和猪尿）中的定量检测技术。
Biochem/physiol Actions
磺胺二甲嘧啶是一种抗微生物性硫药，通过抑制二氢喋呤合成酶而阻断二氢叶酸的合成。磺胺二甲嘧啶是细菌合成叶酸所需的对氨基苯甲酸 (PABA) 的竞争性抑制剂。诱导 CYP3A4 表达并被 N-乙酰转移酶乙酰化。它表现出性别依赖性药代动力学，由男性特有的 CYP2C11 亚型代谢。磺胺二甲嘧啶具有抑菌作用。
General description
化学结构：磺胺
Other Notes
保存于密闭容器内，置于干燥通风处。
Packaging
25G,100G
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Bożena Czubat et al.
Frontiers in microbiology, 11, 2008-2008 (2020-09-26)
MSMEG_4305 is a two-domain protein of Mycolicibacterium smegmatis (Mycobacterium smegmatis) (Mycolicibacterium smegmatis). The N-terminal domain of MSMEG_4305 encodes an RNase H type I. The C-terminal domain is a presumed CobC, predicted to be involved in the aerobic synthesis of vitamin
A D Mitchell et al.
Drug metabolism and disposition: the biological fate of chemicals, 14(2), 161-165 (1986-03-01)
Swine weighing 60-70 kg were orally administered 14C-sulfamethazine [4-amino-N-(4,6-dimethyl-2-pyrimidinyl)benzene[U-14C]sulfonamide] at 12-hr intervals for 7 days (165 mg/dose; 0.126-5.04 mCi/mmol). The animals were sacrificed at 8 hr or 2, 5, or 10 days after the last dose was given and tissues
Tangbin Yang et al.
Hybridoma (2005), 29(5), 403-407 (2010-11-06)
A specific monoclonal antibody (MAb) against sulfamethazine was produced with hybridoma technology. This assay shows very high sensitivity with IC50 of 0.4 ng/mL and LOD of 0.05 ng/mL when it was run in 0.02 mol/L PBS (pH 7.5). This MAb has shown high
C J Chapron et al.
Journal of clinical pharmacology, 16(7), 338-344 (1976-07-01)
The relationship between sulfamethazine disposition kinetics and acetylation phenotype was studied in man. Sulfamethazine pharmacokinetic parameters were determined after the administration of the drug as an oral suspension. When the half-life, acetylation rate constant, or per cent available dose excreted
Craig Knox et al.
Nucleic acids research, 39(Database issue), D1035-D1041 (2010-11-10)
DrugBank (http://www.drugbank.ca) is a richly annotated database of drug and drug target information. It contains extensive data on the nomenclature, ontology, chemistry, structure, function, action, pharmacology, pharmacokinetics, metabolism and pharmaceutical properties of both small molecule and large molecule (biotech) drugs.
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