Quality Level
assay
≥98%
form
powder
storage condition
(Keep container tightly closed in a dry and well-ventilated place.)
color
white to off-white
solubility
H2O: soluble 50 mg/mL
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
mode of action
DNA synthesis | interferes, enzyme | inhibits
storage temp.
2-8°C
SMILES string
[Na].Cc1cc(C)nc(NS(=O)(=O)c2ccc(N)cc2)n1
InChI
1S/C12H14N4O2S.Na.H/c1-8-7-9(2)15-12(14-8)16-19(17,18)11-5-3-10(13)4-6-11;;/h3-7H,13H2,1-2H3,(H,14,15,16);;
InChI key
WIVZAHIZHZEEOX-UHFFFAOYSA-N
General description
化学结构:磺胺
Application
磺胺二甲嘧啶是一种抗生素,在临床上用于治疗支气管炎、前列腺炎和尿路感染。用于处置和消除动力学研究。其用于开发液体(如牛奶、蜂蜜和猪尿)中的定量检测技术。
Biochem/physiol Actions
磺胺二甲嘧啶是一种抗微生物性硫药,通过抑制二氢喋呤合成酶而阻断二氢叶酸的合成。磺胺二甲嘧啶是细菌合成叶酸所需的对氨基苯甲酸 (PABA) 的竞争性抑制剂。诱导 CYP3A4 表达并被 N-乙酰转移酶乙酰化。它表现出性别依赖性药代动力学,由男性特有的 CYP2C11 亚型代谢。磺胺二甲嘧啶具有抑菌作用。
Packaging
25G,100G
Other Notes
保存于密闭容器内,置于干燥通风处。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
A D Mitchell et al.
Drug metabolism and disposition: the biological fate of chemicals, 14(2), 161-165 (1986-03-01)
Swine weighing 60-70 kg were orally administered 14C-sulfamethazine [4-amino-N-(4,6-dimethyl-2-pyrimidinyl)benzene[U-14C]sulfonamide] at 12-hr intervals for 7 days (165 mg/dose; 0.126-5.04 mCi/mmol). The animals were sacrificed at 8 hr or 2, 5, or 10 days after the last dose was given and tissues
Bożena Czubat et al.
Frontiers in microbiology, 11, 2008-2008 (2020-09-26)
MSMEG_4305 is a two-domain protein of Mycolicibacterium smegmatis (Mycobacterium smegmatis) (Mycolicibacterium smegmatis). The N-terminal domain of MSMEG_4305 encodes an RNase H type I. The C-terminal domain is a presumed CobC, predicted to be involved in the aerobic synthesis of vitamin
Tangbin Yang et al.
Hybridoma (2005), 29(5), 403-407 (2010-11-06)
A specific monoclonal antibody (MAb) against sulfamethazine was produced with hybridoma technology. This assay shows very high sensitivity with IC50 of 0.4 ng/mL and LOD of 0.05 ng/mL when it was run in 0.02 mol/L PBS (pH 7.5). This MAb has shown high
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| S5637-100G | 04061836954666 |
| S5637-25G | 04061836954673 |
