跳转至内容
Merck
CN

S5822

Sigma-Aldrich

Spergualin 三盐酸盐

>95% (HPLC and TLC), from Bacillus laterosporus

别名:

Antibiotic BMG 162aF2, Heptanamide,7-[(aminoiminomethyl)amino]-N-[(1S)-2-[[4-[(3-aminopropyl)amino]butyl]amino]-1-hydroxy-2-oxoethyl]-3-hydroxy-,3S)-trihydrochloride

登录查看公司和协议定价

选择尺寸

关于此项目

经验公式（希尔记法）:
C17H40Cl3N7O4
化学文摘社编号:
80952-47-2
分子量:
512.90
UNSPSC代码:
12352200

主要文件

查看所有文档
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

生物来源

Bacillus laterosporus

方案

>95% (HPLC and TLC)

储存条件

desiccated

溶解性

H2O: soluble
acetone: insoluble
ethanol: insoluble
ethyl acetate: insoluble
methanol: soluble

抗生素抗菌谱

neoplastics

运输

wet ice

储存温度

−20°C

InChI

1S/C17H37N7O4.3ClH/c18-7-5-9-21-8-3-4-10-22-15(27)16(28)24-14(26)12-13(25)6-1-2-11-23-17(19)20;;;/h13,16,21,25,28H,1-12,18H2,(H,22,27)(H,24,26)(H4,19,20,23);3*1H/t13-,16-;;;/m0.../s1

InChI key

XWNJZPKETIWTTF-RIHGSVRJSA-N

应用

Spergualin trihydrochloride was used to compare the 15-deoxyspergualin, a derivative of spergualin by thin layer chromatography.1

生化/生理作用

Spergualin is an antibiotic isolated from Bacillus laterosporus that has antibacterial, antitumor, and strong immunosuppressive properties. Spergualin exhibits antitumor activity against transplantable leukemias in mice such as lymphatic leukemia L1210, monocytic leukemia P388, mastocytoma P815, or thymoma EL-4. Spergualin was found effective in inhibiting skin graft rejection, preventing GVHD (Graft-Versus-Host-Disease) in mice recipients of allogeneic bone marrow and spleen cells, and modulating other immunologic diseases.
Spergualin is an antibiotic that posses antibacterial, antitumor, and strong immunosuppressive properties.

制备说明

Spergulain is very soluble in water and methanol. It is slighly or not soluble in ethanol, ethyl acetate, acetone cyclohexane, and other organic solvents. Spergualin solutions are unstable at acidic pH (pH <2) and at highly alkaline pH (pH >9). The powder is highly hygroscopic.

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H315,H319,H335

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

法规信息

新产品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our 文件 section.

如需帮助，请联系 客户支持

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Christopher G Evans et al.
Bioorganic & medicinal chemistry letters, 21(9), 2587-2590 (2011-03-23)
Spergualin is a natural product that exhibits immunosuppressive, anti-tumor and anti-bacterial activities. Its derivatives, such as 15-deoxyspergualin (15-DSG), have been clinically approved for acute allograft rejection. However, the reported syntheses are cumbersome (>10 steps) and they suffer from low overall

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持