S6076
Siomycin A
from Streptomyces sioyaensis, ≥98% (HPLC)
别名:
Antibiotic 6741-21, Mutabillicin, Mutabilycin, Sporangiomycin
生物来源
Streptomyces sioyaensis
质量水平
方案
≥98% (HPLC)
溶解性
DMSO: complete 10 mg/ml, clear, colorless to faintly yellow
DMSO: soluble
储存温度
−20°C
一般描述
Siomycin A is a member of the thiazole antibiotics family.
应用
Siomycin A from Streptomyces sioyaensis yields clear, colorless to faint yellow solution in DMSO at 10 mg/ml.
Siomycin A from Streptomyces sioyaensis may be used in cell signaling studies.
Siomycin A has been used as a forkhead box protein M1 (FOXM1) inhibitor to study the effect of pharmacological inhibition of FOXM1 on isocitrate dehydrogenases 1 (IDH1) protein levels.
生化/生理作用
Siomycin A is a macrocyclic antibiotic with potent and selective antibacterial activity against gram negative and gram positive bacteria, including Mcobacterium tuberculosis and other clinical resistant strains. Siomycin inhibits antibody production and also inhibits the oncogenic transcription factor forkhead box M1 (FoxM1). Siomycin A has been shown to reduce anchorage-independent growth of cells in soft agar. Moveover in vitro asays show that Siomycin A selectively induces apoptosis of transformed, but not normal cells.
Siomycin A is a macrocyclic antibiotic with potent and selective antibacterial activity.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
N J Clayden et al.
European journal of biochemistry, 123(1), 127-131 (1982-03-01)
A trial application of a recent two-dimensional nuclear magnetic resonance experiment to the polypeptide antibiotic siomycin A is described. Proton--carbon-13 chemical shift correlation measures the proton and carbon-13 chemical shift for each directly bonded CH group in a molecule, in
K Tokura et al.
The Journal of antibiotics, 34(7), 800-810 (1981-07-01)
The peptide antibiotic siomycin-A was transformed into half-esters with dicarboxylic acids with the intention of making siomycin-A soluble in water. Sodium salts of the half-esters were also prepared. Some of the salts showed antibacterial activities comparable to siomycin-A against Gram-positive
Thiazole antibiotics against breast cancer.
Marianna Halasi et al.
Cell cycle (Georgetown, Tex.), 9(6), 1214-1217 (2010-04-23)
Bulbul Pandit et al.
The Prostate, 70(8), 825-833 (2010-01-09)
We previously described the identification of a transcriptional inhibitor ARC and FoxM1 inhibitors, thiazole antibiotics, Siomycin A and thiostrepton that were able to induce potent p53-independent apoptosis in cancer cell lines of different origin. Here, we report the characterization of
Tomonori Mori et al.
Chemistry, an Asian journal, 3(6), 984-1012 (2008-05-09)
The five practical segments for the total synthesis of siomycin A, that is, the dehydropiperidine segment A (5), the pentapeptide segment B (3), the dihydroquinoline segment C (6), and the beta-phenylselenoalanine dipeptide segments D (7) and E (4), were synthesized.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持