S6193
SG-209
solid, ≥98% (HPLC)
别名:
N-[2-(Acetoxy)ethyl]-3-pyridinecarboxamide
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关于此项目
经验公式（希尔记法）:
C10H12N2O3
化学文摘社编号:
分子量:
208.21
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
desiccated, protect from light
description
air sensitive
assay
≥98% (HPLC)
form
solid
storage condition
desiccated, protect from light
color
tan
solubility
DMSO: soluble ~24 mg/mL, H2O: insoluble
storage temp.
−20°C
SMILES string
CC(=O)OCCNC(=O)c1cccnc1
InChI
1S/C10H12N2O3/c1-8(13)15-6-5-12-10(14)9-3-2-4-11-7-9/h2-4,7H,5-6H2,1H3,(H,12,14)
InChI key
JQICNNKLTFYSLS-UHFFFAOYSA-N
Application
SG-209 may be used in cell signaling studies.
Biochem/physiol Actions
Potassium channel activator; analog of nicorandil; nitrate-free coronary vasodilator
SG-209, a derivative of nicorandil, opens up potassium channels and leads to vasodilation. It dilates tracheal smooth muscle and increases the blood flow to the trachea in dogs.3
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
S Abe et al.
The Journal of pharmacology and experimental therapeutics, 268(2), 762-771 (1994-02-01)
By using front-surface fluorometry and fura-2-loaded strips of the rabbit femoral artery, the effects of 2-nicotinamidoethyl nitrate (nicorandil) on cytosolic Ca++ concentration ([Ca++]i) and on tension development were measured simultaneously, and findings were compared with those of SG-209 (2-nicotinamidoethyl acetate)
M Maruyama et al.
Archives internationales de pharmacodynamie et de therapie, 258(2), 260-266 (1982-08-01)
In anesthetized dogs, the tracheal vascular bed in situ was perfused with arterial blood through the cannulated cranial thyroid arteries. The effects of nicorandil, a coronary vasodilator, and its congeners (SG-212, GS-209 and SG-103; in which the nitroxy group of
K Satoh et al.
Cardiovascular drugs and therapy, 8(2), 227-234 (1994-04-01)
The vasodilator and negative inotropic mechanisms of action of nicorandil and its congeners (SG-209, SG-103, and SG-86) were investigated in isolated canine papillary muscle preparations cross-circulated through the anterior septal artery with support dogs. SG-209, SG-103, and SG-86 were obtained
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| S6193-50MG | 04061832575896 |
| S6193-10MG | 04061832575889 |