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Merck
CN

S6256

磺胺二甲基嘧啶

99.0-101.0% (on dried basis)

别名:

4,6-二甲基磺胺嘧啶, 4-氨基-N-(4,6-二甲基-2-嘧啶基)苯磺酰胺, 磺胺二甲嘧啶

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关于此项目

经验公式(希尔记法):
C12H14N4O2S
化学文摘社编号:
分子量:
278.33
UNSPSC Code:
51284910
NACRES:
NA.85
PubChem Substance ID:
EC Number:
200-346-4
Beilstein/REAXYS Number:
261304
MDL number:
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Quality Level

assay

99.0-101.0% (on dried basis)

form

powder or crystals

storage condition

(Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)

color

white to off-white

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

DNA synthesis | interferes, enzyme | inhibits

storage temp.

2-8°C

SMILES string

Cc1cc(C)nc(NS(=O)(=O)c2ccc(N)cc2)n1

InChI

1S/C12H14N4O2S/c1-8-7-9(2)15-12(14-8)16-19(17,18)11-5-3-10(13)4-6-11/h3-7H,13H2,1-2H3,(H,14,15,16)

InChI key

ASWVTGNCAZCNNR-UHFFFAOYSA-N

General description

化学结构式:磺酰胺

Application

磺胺二甲嘧啶是一种抗生素,用于治疗支气管炎、前列腺炎和尿路感染。用于处置和消除动力学研究。其用于开发液体(如牛奶、蜂蜜和猪尿)中的定量检测技术

Biochem/physiol Actions

一种抗微生物的硫磺药物。诱导 CYP3A4 表达并被 N-乙酰转移酶乙酰化。表现出性别依赖性药代动力学,由男性特有的 CYP2C11 亚型代谢。
磺胺二甲嘧啶是一种抗微生物性硫药,通过抑制二氢喋呤合成酶而阻断二氢叶酸的合成。磺胺二甲嘧啶是细菌合成叶酸所需的对氨基苯甲酸 (PABA) 的竞争性抑制剂。诱导 CYP3A4 表达并被 N-乙酰转移酶乙酰化。它表现出性别依赖性药代动力学,由男性特有的 CYP2C11 亚型代谢。磺胺二甲嘧啶具有抑菌作用。

Packaging

25G,100G

Other Notes

将容器密闭保存在干燥和通风良好的地方。在干燥处保存。


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存储类别

11 - Combustible Solids

ppe

Eyeshields, Gloves, type N95 (US)

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Skin Irrit. 2

flash_point_f

Not applicable

flash_point_c

Not applicable



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Tangbin Yang et al.
Hybridoma (2005), 29(5), 403-407 (2010-11-06)
A specific monoclonal antibody (MAb) against sulfamethazine was produced with hybridoma technology. This assay shows very high sensitivity with IC50 of 0.4 ng/mL and LOD of 0.05 ng/mL when it was run in 0.02 mol/L PBS (pH 7.5). This MAb has shown high
A D Mitchell et al.
Drug metabolism and disposition: the biological fate of chemicals, 14(2), 161-165 (1986-03-01)
Swine weighing 60-70 kg were orally administered 14C-sulfamethazine [4-amino-N-(4,6-dimethyl-2-pyrimidinyl)benzene[U-14C]sulfonamide] at 12-hr intervals for 7 days (165 mg/dose; 0.126-5.04 mCi/mmol). The animals were sacrificed at 8 hr or 2, 5, or 10 days after the last dose was given and tissues
Marc Teixidó et al.
Environmental science & technology, 45(23), 10020-10027 (2011-10-27)
Adsorption of ionizable compounds by black carbon is poorly characterized. Adsorption of the veterinary antibiotic sulfamethazine (SMT; a.k.a., sulfadimidine; pK(a1) = 2.28, pK(a2) = 7.42) on a charcoal was determined as a function of concentration, pH, inorganic ions, and organic



全球贸易项目编号

货号GTIN
S6256-100G04061838345547
S6256-25G04061835522545