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S6321

Suptopin-2

Name: Suptopin-2
Brand: SIGMA

≥98% (HPLC), solid

别名:

4-Hydroxy-3-[3-(4-hydroxy-3,5-dimethyoxyphenyl)-1-oxo-2-propenyl]-6-methyl-2H-pyran-2-one, Suppressor of Topoisomerase II Inhibition

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关于此项目

经验公式（希尔记法）:

C₁₇H₁₆O₇

化学文摘社编号:

331852-66-5

分子量:

332.30

NACRES:

NA.77

PubChem Substance ID:

24724619

UNSPSC Code:

12352202

MDL number:

MFCD00810236

Assay:

≥98% (HPLC)

Form:

solid

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属性

assay

≥98% (HPLC)

form

solid

solubility

DMSO: 11 mg/mL

storage temp.

2-8°C

SMILES string

COc1cc(\C=C\C(=O)C2=C(O)C=C(C)OC2=O)cc(OC)c1O

InChI

1S/C17H16O7/c1-9-6-12(19)15(17(21)24-9)11(18)5-4-10-7-13(22-2)16(20)14(8-10)23-3/h4-8,19-20H,1-3H3/b5-4+

InChI key

NCXJIWTVFHYSKF-SNAWJCMRSA-N

说明

Application

Suptopin-2 may be used to study cell signaling leading to cell cycle arrest.

Biochem/physiol Actions

Suptopin-2 affects cell cycle progression and stability of microtubules. It induces cell cycle arrest by regulating the nucleocytoplasmic transport of cyclin B1.¹

Sutopin-2 is a suppressor of topoisomerase II inhibition. Reverses cell cycle arrest; bypass of checkpoint function. Has inherent fluorescence and a distinct advantage in identification of molecule targets; effective concentraion in the μM range.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number

036K4610

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Small molecule modulation of the human chromatid decatenation checkpoint.

Stephen J Haggarty et al.

Chemistry & biology, 10(12), 1267-1279 (2004-01-01)

After chromosome replication, the intertwined sister chromatids are disentangled by topoisomerases. The integrity of this process is monitored by the chromatid decatenation checkpoint. Here, we describe small molecule modulators of the human chromatid decatenation checkpoint identified using a cell-based, chemical

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货号	GTIN
S6321-10MG	04061832274102