S7004
鞘髓磷脂
from bovine brain, ≥97.0%, powder
别名:
N-Acyl-4-sphingenyl-1-O-phosphorylcholine, N-酰基-D-鞘氨醇-1-磷酸胆碱
InChI key
LRYZPFWEZHSTHD-HEFFAWAOSA-O
InChI
1S/C24H49N2O6P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-24(28)23(25-22-27)21-32-33(29,30)31-20-19-26(2,3)4/h17-18,22-24,28H,5-16,19-21H2,1-4H3,(H-,25,27,29,30)/p+1/b18-17+/t23-,24+/m0/s1
SMILES string
CCCCCCCCCCCCC/C=C/[C@H]([C@@H](NC=O)COP(O)(OCC[N+](C)(C)C)=O)O
biological source
bovine brain
assay
≥97.0%
form
powder
color
white
storage temp.
−20°C
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Application
Sphingomyelin was used as exogenous treatment to study the effect on ATP depletion and Fe-mediated cell injury in human proximal tubular cell line, HK-2 cells.3 It was used to study the effect on Akt phosphorylation in obese mice.4
Biochem/physiol Actions
Sphingomyelin (SM) is a sphingolipid found in the myelin sheath and cell membranes of animals. The regulation of SM content by sphingomyelinase and SM synthase 2 affect the membrane properties and signaling.1 Excess oxysterols result in increased amount of SM and calcium ions that is the main reason for artery blockage and atherosclerosis.2
Other Notes
Contains primarily stearic, nevonic, and lignoceric acids.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
I Bankov et al.
Folia parasitologica, 45(4), 257-260 (1998-12-30)
Sphingolipids are a diverse and ubiquitous group of lipids. They are widely distributed in parasites and a number of novel forms have been described. Sphingolipid synthesis has been investigated in the malarial parasite, cestodes, digeneans and nematodes. Although there are
N A Babenko et al.
Biochemistry. Biokhimiia, 64(8), 912-915 (1999-09-28)
Inhibition of thyroid gland function in rats with mercasolil sharply decreased thyroxine and triiodothyronine levels in blood serum and increased acid sphingomyelinase activity and sphingomyelin content in liver. Thyroxine injected into hypothyroid rats normalized the sphingomyelin content, reduced the free
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