S7029
[Pro9]-Substance P
≥97% (HPLC)
别名:
Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Pro-Leu-Met-NH2
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关于此项目
经验公式（希尔记法）:
C66H102N18O13S
化学文摘社编号:
分子量:
1387.69
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
方案
≥97% (HPLC)
储存温度
−20°C
SMILES字符串
CSCCC(NC(=O)C(CC(C)C)NC(=O)C1CCCN1C(=O)C(Cc2ccccc2)NC(=O)C(Cc3ccccc3)NC(=O)C(CCC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C4CCCN4C(=O)C(CCCCN)NC(=O)C5CCCN5C(=O)C(N)CCCNC(N)=N)C(N)=O
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
涉药品监管产品
此项目有
F Petitet et al.
Journal of neurochemistry, 56(3), 879-889 (1991-03-01)
Previous studies have indicated that [Pro9]-substance P ([Pro9]-SP) possesses very good affinity for NK-1 binding sites and that, in contrast to substance P, it interacts selectively with these sites. Therefore, [3H][Pro9]-SP (75 Ci/mmol) was synthesized in order to study its
G Chassaing et al.
Neuropeptides, 23(2), 73-79 (1992-10-01)
Structural considerations led us to postulate that the introduction of the dipeptides DPro9-Pro10 and DPro9-MeLeu10 should lock the C-terminal tetrapeptide of SP in a type II' beta-turn structure, a prerequisite for antagonist activity. Indeed, as the GR 71251, [DPro9, Pro10
S Ravard et al.
Brain research, 651(1-2), 199-208 (1994-07-18)
Potent and selective NK-1 and NK-2 agonists as well as compounds with lower selectivity and affinity for NK-1 binding sites were compared in their ability to produce scratching and grooming behaviours when injected intracerebroventricularly in mice. Septide, an agonist with
U Liminga et al.
Behavioural brain research, 57(1), 93-99 (1993-10-21)
Bilateral intranigral infusions of three different peptide agonists were made in rats exposed to fluphenazine decanoate, 30 mg/kg/month (FLU) or vehicle (CON) for seven months. Oral movements were monitored repeatedly during the neuroleptic pretreatment period, as well as before the
S Sagan et al.
Biochemical and biophysical research communications, 282(4), 958-964 (2001-05-16)
The internalization of [3H]propionyl[Met(O2)11]SP(7-11) which binds one binding site and of [3H][Pro9]SP which binds the two binding sites associated with the NK-1 receptor has been examined in CHO cells. The quantity of [3H][Pro9]SP measured inside the cytoplasm in kinetic experiments
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