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文件

S7771

Sigma-Aldrich

(S)-(-)-止呕灵

≥98% (titration)

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别名:
(S)-5-氨基磺酰基-N-[(1-乙基-2-吡咯烷基)甲基]-2-甲氧基苯甲酰胺, 左舒必利
经验公式（希尔记法）:
C15H23N3O4S
CAS号:
23672-07-3
分子量:
341.43
MDL编号:
MFCD00055220
PubChem化学物质编号:
24278709
NACRES:
NA.77

质量水平

100

检测方案

≥98% (titration)

mp

183-186 °C (lit.)

创始人

Sanofi Aventis

储存温度

2-8°C

SMILES字符串

CCN1CCC[C@H]1CNC(=O)c2cc(ccc2OC)S(N)(=O)=O

InChI

1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21)/t11-/m0/s1

InChI key

BGRJTUBHPOOWDU-NSHDSACASA-N

基因信息

human ... DRD2(1813) , DRD3(1814)
rat ... Adra1a(29412) , Drd2(24318) , Drd3(29238) , Htr1a(24473) , Htr2a(29595)

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应用

(S)-(−)-Sulpiride was used to study the effect of dopamine D2 receptor function on activation of KCNQ potassium channels10 and on depression-like behavior in ovariectomized female rats.11

生化/生理作用

(S)-(−)-Sulpiride or Levosulpiride blocks the inhibitory enteric D2 receptors (neuronal and muscular). It has prokinetic activity and is effective in the treatment of functional dyspepsia and gastroparesis in insulin-dependent diabetes mellitus patients.7,8 Since dopamine controls human sexual function, (S)-(−)-Sulpiride is reportedly effective in treatment of erectile dysfunctions.9
D2 多巴胺受体拮抗剂；安定药。

特点和优势

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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P Melga et al.
Diabetes care, 20(1), 55-58 (1997-01-01)
We evaluated the effect of chronic administration of levosulpiride, a prokinetic drug that is a selective antagonist for D2 dopamine receptors, on the glycemic control of IDDM subjects. The study was performed on 40 long-standing IDDM subjects with clinical signs
K László et al.
Hormones and behavior, 124, 104777-104777 (2020-05-23)
Neuropeptide oxytocin (OT) is involved in the regulation of social and non-social behaviour. The central nucleus of amygdala (CeA), part of the limbic system, plays an important role in learning, memory, anxiety and reinforcing mechanisms. CeA has been shown to
Hae-Won Shin et al.
Movement disorders : official journal of the Movement Disorder Society, 24(15), 2249-2253 (2009-10-02)
Levosulpiride is a substituted benzamide that is widely used for the management of dyspepsia and emesis. However, little is known about levosulpiride-induced movement disorders (LIM). The aim of this study was to investigate the clinical characteristics of patients with LIM.
Fermín Mearin et al.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2(4), 301-308 (2004-04-07)
Levosulpiride is a benzamide derivate D(2) dopamine antagonist with prokinetic activity that can accelerate gastric emptying and reduce discomfort in response to gastric distention. The aim of the study is to compare the clinical efficacy of levosulpiride and cisapride in
E Distrutti et al.
Alimentary pharmacology & therapeutics, 16(3), 613-622 (2002-03-06)
Altered visceral perception is common in functional dyspepsia (FD). Dopaminergic pathways control gastrointestinal motility, but whether they modulate visceral sensitivity is unknown. To investigate whether levosulpiride, a D2 antagonist, modulates gastric sensitivity and compliance in dyspeptic patients. Eight healthy subjects
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