跳转至内容
Merck
CN

S8072

Sigma-Aldrich

Sertindole

≥97.5% (HPLC)

别名:

1-[2-[4-[5-chloro-1-(4-fluorophenyl)-1h-indol-3-yl]-1-piperidinyl]ethyl]-2-imidazolidinone

登录查看公司和协议定价

选择尺寸

关于此项目

经验公式（希尔记法）:
C24H26ClFN4O
化学文摘社编号:
106516-24-9
分子量:
440.94
MDL编号:
MFCD00867749
UNSPSC代码:
12352200
PubChem化学物质编号:
329824596
NACRES:
NA.77

主要文件

查看所有文档
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

方案

≥97.5% (HPLC)

表单

solid

颜色

off-white

溶解性

DMSO: >10 mg/mL
H2O: <2 mg/mL

创始人

Abbott

储存温度

2-8°C

SMILES字符串

Fc1ccc(cc1)-n2cc(C3CCN(CC3)CCN4CCNC4=O)c5cc(Cl)ccc25

InChI

1S/C24H26ClFN4O/c25-18-1-6-23-21(15-18)22(16-30(23)20-4-2-19(26)3-5-20)17-7-10-28(11-8-17)13-14-29-12-9-27-24(29)31/h1-6,15-17H,7-14H2,(H,27,31)

InChI key

GZKLJWGUPQBVJQ-UHFFFAOYSA-N

基因信息

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), DRD2(1813)

应用

Sertindole was used to study the role of 5-HT2C receptor in antipsychotic-induced body weight gain in rats.3

生化/生理作用

Sertindole is a 5-HT2 serotonin and D2 dopamine receptor antagonist and antipsychotic.
Sertindole readily passes the blood-brain barrier and is metabolized into compounds that show greater affinity for 5-HT2 receptors and less for D2 receptors. It is an effective treatment agent for schizophrenia as it improves cognitive impairment.1 Sertindole also acts as antagonist to human cardiac potassium channel, HERG and produces prolonged QT interval.2

特点和优势

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险分类

Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000100531
0000056972
0000056983
0000049060
0000012635

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Tomasz Kos et al.
Psychopharmacology, 214(4), 911-921 (2010-12-17)
Cognitive deficits, including an impaired ability to shift perceptual attentional set, belong to the core features of schizophrenia, are associated with prefrontal cortical dysfunctions, and may involve glutamate NMDA receptors. Although phencyclidine disturbs cognitive flexibility, little is known about the
Katja Komossa et al.
The Cochrane database of systematic reviews, (2)(2), CD006752-CD006752 (2009-04-17)
In many countries of the industrialised world second generation (atypical) antipsychotics have become the first line drug treatment for people with schizophrenia. The question as to whether and, if so, how much the effects of the various second generation antipsychotics
Anna Secher et al.
Neuroendocrinology, 91(2), 155-168 (2009-10-10)
Body weight gain is a common side effect of treatment with antipsychotics, but the mechanisms underlying this weight gain are unknown. Several factors may be involved in antipsychotic-induced body weight gain including the cannabinoid receptor 1 (CB(1)), the serotonin receptor
Eva Lindström et al.
The international journal of neuropsychopharmacology, 8(4), 615-629 (2005-06-21)
Since the 1960s, physicians have been aware of electrocardiographic (ECG) abnormalities and cases of sudden death associated with the use of antipsychotic drugs in patients with schizophrenia. Explanations for such deaths have traditionally focused on drug-induced prolongation of the QT
René Ernst Nielsen et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 22(10), 747-750 (2012-03-24)
Drug attitude inventory (DAI-30) is considered to be the best predictor of poor adherence in first-episode schizophrenia. We compared the short version (DAI-10) with DAI-30 in long-term schizophrenia, documented if DAI was associated with poor insight, PANSS and GAF and
查看所有相关文献

商品

Dopamine Receptors

We offer many products related to dopamine receptors for your research needs.

多巴胺受体

我们可提供多种多巴胺受体相关的产品，满足您的各类研究需求。

Serotonin Receptors

We offer many products related to serotonin receptors for your research needs.

血清素受体

我们提供许多血清素受体相关产品，满足您的各类研究需求。

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持