S8194
Salicylidene salicylhydrazide
≥98% (HPLC), solid
别名:
2-Hydroxybenzylidene 2-hydroxybenzhydrazide, NSC 87864, SCS
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关于此项目
经验公式（希尔记法）:
C14H12N2O3
化学文摘社编号:
分子量:
256.26
UNSPSC Code:
12352200
PubChem Substance ID:
EC Number:
221-773-2
MDL number:
InChI key
OMCYEZUIYGPHDJ-OQLLNIDSSA-N
InChI
1S/C14H12N2O3/c17-12-7-3-1-5-10(12)9-15-16-14(19)11-6-2-4-8-13(11)18/h1-9,17-18H,(H,16,19)/b15-9+
SMILES string
Oc1ccccc1\C=N\NC(=O)c2ccccc2O
assay
≥98% (HPLC)
form
solid
color
off-white
solubility
DMSO: ~20 mg/mL, H2O: insoluble
Application
Salicylidene salicylhydrazide may be used in GABAA receptor-mediated cell signaling studies.
Biochem/physiol Actions
Potent and selective inhibitor of α2β1γ1δ GABAA receptor subtype.
Potent, selective inhibitor of α2β1γ1δ GABAA receptor subtype.
Salicylidene salicylhydrazide interacts with threonine 255 located with transmembrane domain 1 and isoleucine 308 located extracellularly of the GABAA receptors with β1 subunit and allosterically inhibits them.3 It decreased the abnormal prion protein and increased the normal prion protein level in prion-infected neuroblastoma cells.4
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
E W Ainscough et al.
Journal of inorganic biochemistry, 77(3-4), 125-133 (2000-01-22)
A series of salicylaldehyde benzoylhydrazone derivatives, their copper(II) complexes and a range of transition metal complexes of the unsubstituted ligand has been synthesized and evaluated for cytotoxicity against a human adenocarcinoma cell line. A QSAR analysis revealed ligand cytotoxicity is
S A Thompson et al.
British journal of pharmacology, 142(1), 97-106 (2004-04-22)
1. A high-throughput assay utilizing the voltage/ion probe reader (VIPR) technology identified salicylidene salicylhydrazide (SCS) as being a potent selective inhibitor of alpha2beta1gamma1 GABA(A) receptors with a maximum inhibition of 56+/-5% and an IC(50) of 32 (23, 45) nm. 2.
Yuri A Blednov et al.
Neuropharmacology, 178, 108220-108220 (2020-08-01)
Phosphodiesterase type 4 (PDE4) inhibitors prevent hydrolysis of cyclic adenosine monophosphate and increase protein kinase A (PKA)-mediated phosphorylation. PDE4 inhibitors also regulate responses to ethanol and GABAergic drugs. We investigated mechanisms by which the PDE4 inhibitor, apremilast, regulates acute effects
Tomohiro Kimura et al.
FEBS letters, 584(6), 1193-1198 (2010-02-18)
Gamma-aminobutyric acid type A (GABAA) receptor beta1 (gabrb1), a subunit of GABAA receptors involved in inhibitory effects on neurotransmission, was found to associate with the formation of protease-resistant prion protein in prion-infected neuroblastoma cells. Silencing of gabrb1 gene expression significantly
Lala Rukh et al.
European journal of pharmacology, 888, 173481-173481 (2020-08-14)
Chemotherapy-induced peripheral neuropathy (CIPN) is an increasingly important problem for cancer survivors and is the foremost cause of drug-induced morbidity. In this study, the antinociceptive efficacy of salicylidene salicylhydrazide (SSH) in CIPN was investigated. SSH was evaluated for acute toxicity
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