方案
≥98% (HPLC)
颜色
white
溶解性
DMSO: soluble ≥19 mg/mL
SMILES字符串
ONC(=O)CCCCCCC(=O)Nc1ccccc1
InChI
1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
InChI key
WAEXFXRVDQXREF-UHFFFAOYSA-N
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生化/生理作用
伏立诺他或辛二酰苯胺异羟肟酸（SAHA）是一种有效的、可逆的泛组蛋白去乙酰化酶（HDAC）抑制剂。其可抑制I类和II类HDAC，从而改变基因转录并诱导多种转化细胞中的细胞周期停滞和/或凋亡。
有效的、可逆的泛组蛋白去乙酰化酶（HDAC）抑制剂。
免责声明
Note: Unstable when in contact with metal, do not use metal spatula when weighing or transferring.
法规信息
新产品
此项目有
Phillipp Kirfel et al.
Archives of insect biochemistry and physiology, 103(3), e21614-e21614 (2019-09-10)
Histone acetylation is an evolutionarily conserved epigenetic mechanism of eukaryotic gene regulation which is tightly controlled by the opposing activities of histone acetyltransferases (HATs) and histone deacetylases (HDACs). In insects, life-history traits such as longevity and fecundity are severely affected
Jui-Hua Hsieh et al.
Chemical research in toxicology, 32(7), 1384-1401 (2019-06-28)
Genotoxicity is a critical component of a comprehensive toxicological profile. The Tox21 Program used five quantitative high-throughput screening (qHTS) assays measuring some aspect of DNA damage/repair to provide information on the genotoxic potential of over 10 000 compounds. Included were assays
Hoon Kim et al.
Scientific reports, 9(1), 9702-9702 (2019-07-06)
Cancer cell stemness is essential for enabling malignant progression and clonal evolution. Cancer cell fate is likely determined by complex mechanisms involving both cell-intrinsic pathways and stress signals from tumor microenvironment. In this study, we examined the role of the
Hunain Alam et al.
Cancer cell, 37(4), 599-617 (2020-04-04)
Epigenetic modifiers frequently harbor loss-of-function mutations in lung cancer, but their tumor-suppressive roles are poorly characterized. Histone methyltransferase KMT2D (a COMPASS-like enzyme, also called MLL4) is among the most highly inactivated epigenetic modifiers in lung cancer. Here, we show that
Mahesh Chemudupati et al.
Journal of virology, 94(16) (2020-05-29)
Butyrate is an abundant metabolite produced by gut microbiota. While butyrate is a known histone deacetylase inhibitor that activates expression of many genes involved in immune system pathways, its effects on virus infections and on the antiviral type I interferon
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