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Merck
CN

S8752

Sigma-Aldrich

琥珀酰磺胺噻唑

≥98%

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关于此项目

经验公式(希尔记法):
C13H13N3O5S2
化学文摘社编号:
分子量:
355.39
Beilstein:
349989
EC 号:
MDL编号:
UNSPSC代码:
51283905
PubChem化学物质编号:
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方案

≥98%

表单

powder

颜色

white to off-white

溶解性

1 M NaOH: soluble 50 mg/mL

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria

作用机制

DNA synthesis | interferes
enzyme | inhibits

SMILES字符串

OC(=O)CCC(=O)Nc1ccc(cc1)S(=O)(=O)Nc2nccs2

InChI

1S/C13H13N3O5S2/c17-11(5-6-12(18)19)15-9-1-3-10(4-2-9)23(20,21)16-13-14-7-8-22-13/h1-4,7-8H,5-6H2,(H,14,16)(H,15,17)(H,18,19)

InChI key

SKVLYVHULOWXTD-UHFFFAOYSA-N

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一般描述

化学结构:磺胺

应用

琥珀酰磺胺噻唑可用于阻断叶酸的合成。它可用于研究叶酸缺乏症。它用于抑制肠道细菌产生叶酸

生化/生理作用

琥珀酰磺胺噻唑是二氢蝶呤合成酶的竞争性抑制剂。它是二氢叶酸还原酶(DHFR)抑制剂。

其他说明

保存于密闭容器内,置于干燥通风处。

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Skin Sens. 1

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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General pharmacology, 16(6), 557-560 (1985-01-01)
The metabolism of methylamine has been investigated in the rat in order to elucidate the role of monoamine oxidase (MAO; EC 1.4.3.4) and intestinal bacteria in the metabolism of the compound. In a series of experiments in which short- and
F M Veronese et al.
Biomaterials, 20(1), 91-98 (1999-01-23)
Membranes or microcapsules made from polyphosphazenes bearing amino acid side groups are proposed for the treatment of periodontal diseases. Polyphosphazene membranes, prepared with alanine ethyl ester and imidazole in the molar ratio of 80:20 as phosphorus substituents, gave a degradation
Toshimori Kitami et al.
Physiological genomics, 35(2), 182-190 (2008-08-14)
Dietary folate supplementation can dramatically reduce the severity and incidence of several common birth defects and adult diseases that are associated with anomalies in homocysteine and folate metabolism. The common polymorphisms that adversely affect these metabolic pathways do not fully
Rodrigue Yossa et al.
Zebrafish, 8(4), 221-227 (2011-10-13)
A study was conducted to preliminarily assess the contribution of the intestinal microflora to biotin supply in zebrafish. Biotin and avidin were added to three isonitrogenous and isocaloric purified diets to provide molar avidin: biotin ratios of 0:0 (basal diet)
Ki-Yeon Yoo et al.
Genes & nutrition, 2(4), 331-336 (2008-10-14)
Folate deficiency increases stroke risk. We examined whether folate deficiency affects platelet endothelial cell adhesion molecule-1 (PECAM-1), which is an immunoglobulin-associated cell adhesion molecule and mediates the final common pathway of neutrophil transendothelial migration, in blood vessels in the gerbil

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