S8752
琥珀酰磺胺噻唑
≥98%
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关于此项目
经验公式（希尔记法）:
C13H13N3O5S2
化学文摘社编号:
分子量:
355.39
EC Number:
204-141-0
UNSPSC Code:
51283905
PubChem Substance ID:
Beilstein/REAXYS Number:
349989
MDL number:
InChI key
SKVLYVHULOWXTD-UHFFFAOYSA-N
InChI
1S/C13H13N3O5S2/c17-11(5-6-12(18)19)15-9-1-3-10(4-2-9)23(20,21)16-13-14-7-8-22-13/h1-4,7-8H,5-6H2,(H,14,16)(H,15,17)(H,18,19)
SMILES string
OC(=O)CCC(=O)Nc1ccc(cc1)S(=O)(=O)Nc2nccs2
assay
≥98%
form
powder
color
white to off-white
solubility
1 M NaOH: soluble 50 mg/mL
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
mode of action
DNA synthesis | interferes, enzyme | inhibits
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General description
化学结构：磺胺
Application
琥珀酰磺胺噻唑可用于阻断叶酸的合成。它可用于研究叶酸缺乏症。它用于抑制肠道细菌产生叶酸。
Biochem/physiol Actions
琥珀酰磺胺噻唑是二氢蝶呤合成酶的竞争性抑制剂。它是二氢叶酸还原酶（DHFR）抑制剂。
Other Notes
保存于密闭容器内，置于干燥通风处。
signalword
Warning
hcodes
Hazard Classifications
Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Toshimori Kitami et al.
Physiological genomics, 35(2), 182-190 (2008-08-14)
Dietary folate supplementation can dramatically reduce the severity and incidence of several common birth defects and adult diseases that are associated with anomalies in homocysteine and folate metabolism. The common polymorphisms that adversely affect these metabolic pathways do not fully
G M Semchuk et al.
The Journal of nutrition, 124(7), 1118-1125 (1994-07-01)
This study was designed to assess the effect of succinylsulfathiazole on the apparent bioavailability of folate added to milk-containing diets. We also evaluated the impact of milk type on the relative bioavailability (bioavailability) of folate following pasteurization (62.5 degrees C
Ki-Yeon Yoo et al.
Genes & nutrition, 2(4), 331-336 (2008-10-14)
Folate deficiency increases stroke risk. We examined whether folate deficiency affects platelet endothelial cell adhesion molecule-1 (PECAM-1), which is an immunoglobulin-associated cell adhesion molecule and mediates the final common pathway of neutrophil transendothelial migration, in blood vessels in the gerbil
S W Choi et al.
Gut, 43(1), 93-99 (1998-10-15)
Diminished folate status appears to promote colonic carcinogenesis by, as of yet, undefined mechanisms. Impaired DNA repair plays a significant role in the evolution of many colon cancers. Since folate is essential for the de novo synthesis of nucleotides and
Rodrigue Yossa et al.
Zebrafish, 8(4), 221-227 (2011-10-13)
A study was conducted to preliminarily assess the contribution of the intestinal microflora to biotin supply in zebrafish. Biotin and avidin were added to three isonitrogenous and isocaloric purified diets to provide molar avidin: biotin ratios of 0:0 (basal diet)
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