S8945
Anti-Syntaxin 8 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
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Conjugate:
unconjugated
Clone:
polyclonal
Application:
ARR, IP, WB
Citations:
3
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 27 kDa
species reactivity
rat
technique(s)
immunoprecipitation (IP): 10-20 μg using NRK cell lysate, microarray: suitable, western blot: 2-4 μg/mL using whole cell extract of the rat kidney NRK cell line and the rat pheochromocytoma PC12 cell line
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... STX8(9482)
mouse ... Stx8(55943)
rat ... Stx8(59074)
General description
Syntaxin 8 (Stx8) is a member of the soluble NSF (N-ethyl-maleimide-sensitive protein) attachment proteins receptor (t-SNARE) family. Syntaxin 8 shares 23% identity with syntaxin 6 and is ubiquitously expressed in multiple tissues, with highest levels in the heart. This protein is anchored to membranes by a C-terminal hydrophobic domain and appears to contain a helical domain. Stx8 is localized to membrane compartments of the early endosome (EE). This protein has two unique di-leucine-based motifs. Stx8 gene is mapped to human chromosome 17p12.
Immunogen
synthetic peptide corresponding to amino acids 117-134 located at the mid-region of rat syntaxin 8, conjugated to KLH. This sequence is identical in mouse syntaxin 8 and highly conserved (two amino acid substitutions) in human syntaxin 8.
Application
Anti-Syntaxin 8 antibody produced in rabbit may be used in immunoblotting and immunoprecipitation.
Biochem/physiol Actions
Syntaxin 8 (Stx8) protein has been suggested to function in clathrin-independent vesicular transport and membrane fusion events necessary for protein transport from the early endosome (EE) to the late endosome (LE). This protein may also participate in vesicular trafficking and docking.
Anti-Syntaxin 8 specifically recognizes rat syntaxin 8 (27 kDa).
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Preparation Note
For continuous use, store at 2-8 °C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing, or storage in "frost-free" freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Syntaxin 8 has two functionally distinct di-leucine-based motifs
Kasai K, et al.
Cellular and Molecular Biology Letters, 13(1), 144-154 (2008)
V Thoreau et al.
Biochemical and biophysical research communications, 257(2), 577-583 (1999-04-13)
We report the cloning of a cDNA encoding human syntaxin 8 (STX8), using the regulator (R) domain of the cystic fibrosis transmembrane conductance regulator (CFTR) as a bait to screen a human fetal lung cDNA library by the yeast two-hybrid
Andoni Lancha et al.
Archives of medical research, 46(1), 47-53 (2014-12-20)
Obesity is associated with increased adipose tissue inflammation as well as with the development of type 2 diabetes (T2D). Syntaxin 8 (STX8) is a protein required for the transport of endosomes. In this study we analyzed the relationship of STX8
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