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Merck
CN

S9132

螺旋霉素

别名:

Rovamycin, Formacidine

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关于此项目

化学文摘社编号:
8025-81-8
EC 号:
232-429-6
MDL编号:
MFCD01314545
UNSPSC代码:
51283208
PubChem化学物质编号:
24899826
NACRES:
NA.85

主要文件

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表单

powder

质量水平

200

旋光性

[α]/D -85 to -80° in water (Specific rotation (dry basis))

效能

≥4100 I.U. per mg (dry basis)

储存条件

(Keep container tightly closed in a dry and well-ventilated place.)

颜色

white to light yellow

溶解性

methanol: soluble

痕量阳离子

heavy metals: ≤20 ppm

抗生素抗菌谱

Gram-positive bacteria

作用机制

protein synthesis | interferes

储存温度

2-8°C

SMILES字符串

CO[C@H]1[C@H](O)CC(=O)O[C@H](C)C\C=C\C=C\[C@H](OC2CCC(C(C)O2)N(C)C)[C@H](C)C[C@H](CC=O)[C@@H]1OC3OC(C)C(OC4CC(C)(O)C(O)C(C)O4)C(C3O)N(C)C

InChI

1S/C43H74N2O14/c1-24-21-29(19-20-46)39(59-42-37(49)36(45(9)10)38(27(4)56-42)58-35-23-43(6,51)41(50)28(5)55-35)40(52-11)31(47)22-33(48)53-25(2)15-13-12-14-16-32(24)57-34-18-17-30(44(7)8)26(3)54-34/h12-14,16,20,24-32,34-42,47,49-51H,15,17-19,21-23H2,1-11H3/b13-12+,16-14+/t24-,25-,26?,27?,28?,29+,30?,31-,32+,34?,35?,36?,37?,38?,39+,40+,41?,42?,43?/m1/s1

InChI key

ACTOXUHEUCPTEW-JMRHEKERSA-N

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相关类别

一般描述

Chemical structure: macrolide

应用

Spiramycin is a macrolide antibiotic that is commonly used to treat infections of soft tissues. It has been used to treat bronchopulmonary infections in adults and has been used to study septicemia in mice .

生化/生理作用

Spiramycin is a 16-membered ring macrolide antibiotic from Streptomyces ambofaciens. It inhibits bacterial protein synthesis at the level of peptidy-tRNA dissociation from ribosomes. It is mainly used against Gram-positive bacteria.

分析说明

A mixture of Spiramycin I, II and III.

其他说明

Keep container tightly closed in a dry and well-ventilated place.

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCV6785
MKCW9212
MKCS9688
MKCQ3681
MKCN6048

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Acute bronchopulmonary infections: treatment with i.v. spiramycin.
F Vachon and S Kernbaum
Chemotherapia, 6, 282-285 (1987)
Ming-juan Wang et al.
Journal of chromatography. A, 1217(42), 6531-6544 (2010-09-17)
Investigation of acetylspiramycin (ASPM) and its related substances was carried out using a reversed-phase liquid chromatography/tandem mass spectrometry method. The identification of impurities in the ASPM complex was performed with a quadrupole ion trap mass spectrometer, with an electrospray ionization
Yonca Acikgoz et al.
Pediatric transplantation, 16(4), E115-E119 (2011-02-16)
Cryptosporidium is an intracellular protozoan parasite that causes gastroenteritis in human. In immunocompromised individuals, cryptosporidium causes far more serious disease. There is no effective specific therapy for cryptosporidiosis, and spontaneous recovery is the rule in healthy individuals. However, immunocompromised patients
I Brook
Clinical pharmacokinetics, 34(4), 303-310 (1998-05-08)
The absolute bioavailability of oral spiramycin is generally within the range of 30 to 40%. After a 1 g oral dose, the maximum serum drug concentration was found to be within the range 0.4 to 1.4 mg/L. The tissue distribution
Severe congenital toxoplasmosis due to a Toxoplasma gondii strain with an atypical genotype: case report and review.
Laurence Delhaes et al.
Prenatal diagnosis, 30(9), 902-905 (2010-06-29)
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