InChI key
PEYUIKBAABKQKQ-AFHBHXEDSA-N
SMILES string
C1Oc2ccc(cc2O1)[C@H]3OC[C@H]4[C@@H]3CO[C@@H]4c5ccc6OCOc6c5
InChI
1S/C20H18O6/c1-3-15-17(25-9-23-15)5-11(1)19-13-7-22-20(14(13)8-21-19)12-2-4-16-18(6-12)26-10-24-16/h1-6,13-14,19-20H,7-10H2/t13-,14-,19+,20+/m0/s1
biological source
Sesamum indicum (sesame)
assay
≥95%
form
crystalline
shipped in
wet ice
storage temp.
−20°C
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General description
芝麻素是存在于芝麻种子中的脂溶性呋喃木酚素。
Application
芝麻素已被用于：
- 作为木酚素用于研究其对大鼠骨髓基质细胞（BMSC）成骨细胞分化的影响
- 作为分离芝麻油中芝麻素的标准品
- 研究其作为内源性木酚素（enterolignan）对雌激素受体（ER）阳性人乳腺癌MCF-7细胞增殖的影响
Biochem/physiol Actions
芝麻素可以降低人体内胆固醇的作用。它参与预防高血压，并增加维生素E水平。芝麻素具有抗癌、抗增殖、抗转移和抗炎特性。它还具有促凋亡和促自噬特性。芝麻素对脂质和碳水化合物的代谢有影响。它还对高血压和自由基清除有影响。
非竞争性δ 5-去饱和酶抑制剂。
signalword
Warning
hcodes
Hazard Classifications
Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Sesamin promotes osteoblastic differentiation and protects rats from osteoporosis
Ma Z, et al.
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 25(16), 5312-5312 (2019)
S Shimizu et al.
Lipids, 26(7), 512-516 (1991-07-01)
Incubation with sesame oil increases the mycelial dihomo-gamma-linolenic acid content of an arachidonic acid-producing fungus, Mortierella alpina, but decreases its arachidonic acid content [Shimizu, S., K. Akimoto, H. Kawashima, Y. Shinmen and H. Yamada (1989) J. Am. Oil Chem. Soc.
Differential and directional estrogenic signaling pathways induced by enterolignans and their precursors
Zhu Y, et al.
Testing, 12(2), e0171390-e0171390 (2017)
N Hirose et al.
Journal of lipid research, 32(4), 629-638 (1991-04-01)
The effects of sesamin, a lignan from sesame oil, on various aspects of cholesterol metabolism were examined in rats maintained on various dietary regimens. When given at a dietary level of 0.5% for 4 weeks, sesamin reduced the concentration of
Amin F Majdalawieh et al.
European journal of pharmacology, 815, 512-521 (2017-10-17)
Sesamin is the major active ingredient is Sesamum indicum seeds. Several studies revealed that sesamin possesses potent anti-cancer properties. The anti-cancer effects of sesamin have been mainly attributed to its anti-proliferative, pro-apoptotic, anti-inflammatory, anti-metastatic, anti- and pro-angiogenic, and pro-autophagocytic activities.
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