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Merck
CN

S9321

Saikosaponin D 来源于银柴胡

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关于此项目

经验公式(希尔记法):
C42H68O13
分子量:
780.98
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
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assay

≥95% (HPLC)

form

powder

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

2-8°C

SMILES string

CC1(C)CC[C@]23[C@H](O)C[C@@]4(C)[C@]5(C)CC[C@@]6([H])[C@@](CO)(C)[C@@H](O[C@]7([H])O[C@H](C)[C@H](O)[C@H](O[C@]8([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O)[C@H]7O)CC[C@]6(C)[C@@]5([H])C=C[C@]4(OC3)[C@]2([H])C1

InChI

1S/C42H68O13/c1-21-28(46)33(55-34-31(49)30(48)29(47)22(18-43)53-34)32(50)35(52-21)54-27-10-11-37(4)23(38(27,5)19-44)8-12-39(6)24(37)9-13-42-25-16-36(2,3)14-15-41(25,20-51-42)26(45)17-40(39,42)7/h9,13,21-35,43-50H,8,10-12,14-20H2,1-7H3/t21-,22-,23-,24-,25-,26-,27+,28+,29-,30+,31-,32-,33+,34+,35+,37+,38+,39-,40+,41-,42+/m1/s1

InChI key

KYWSCMDFVARMPN-LCSVLAELSA-N

Application

Saikosaponins such as Saikosaponin D are used to help analyse and resolve the activities of herbal medicines such as Sho-saiko-to.

Biochem/physiol Actions

Saikosaponin D inhibits cell growth of human cancer cells by inducing apoptosis and blocking cell cycle progression in the G1 phase. Saikosaponin D was found to stimulate corticotropin-releasing factor (CRF) gene expression and CRF release.


存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

法规信息

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I Sakaida et al.
Journal of hepatology, 28(2), 298-306 (1998-03-26)
A herbal medicine, Sho-saiko-to (TJ-9), has recently been orally administered to patients with chronic liver disease in Japan and has been reported to inhibit the development of hepatocellular carcinoma. The aim of this study was to investigate whether TJ-9 has
K Kayano et al.
Journal of hepatology, 29(4), 642-649 (1998-11-21)
It is of extreme importance to prevent liver fibrosis and subsequent progression to liver cirrhosis. The aim of our study was to elucidate in vitro whether Sho-saiko-to exerted inhibitory effects on hepatic stellate cells. Hepatic stellate cells were isolated from
Sho-saiko-to: Japanese herbal medicine for protection against hepatic fibrosis and carcinoma.
Shimizu I.
Journal of Gastroenterology and Hepatology, 15, Suppl D84-Suppl D90 (2000)



全球贸易项目编号

货号GTIN
S9321-1MG04061826168073
S9321-5MG04061833051108