Anti-Sam68 (N-terminal) antibody produced in rabbit

Src-associated in mitosis 68 kDa protein (Sam68/KHDR1) or K homology (KH) domain-containing, RNA binding, signal transduction associated 1 (KHDRBS1) is a member of the signal transducer and activator of RNA (STAR) family of RNA-binding proteins. This protein contains a KH (hnRNP K homology) RNA-binding domain located within a larger domain of 200 amino acids with RNA binding activity named GSG (GRP33/Sam68/GLD-1) domain. The Sam68 gene is mapped to human chromosome 1p35.

Anti-Sam68 (N-terminal) antibody produced in rabbit may be used in immunoblotting.

Anti-Sam68 (N-terminal) recognizes human Sam68.

Src-associated in mitosis 68 kDa protein (Sam68/KHDR1/KHDRBS1) participates in signal transduction, RNA metabolism, apoptosis, transcription, cell cycle, and regulation. Besides binding to RNA and its modulator proteins, Sam68 contains proline-rich motifs and multiple potential tyrosine phosphorylation sites that are involved in the binding to proteins with Src homology 3 (SH3) and SH2 domains. It controls the activation of nuclear transcription factor kappa B (NF-κB).

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Store at –20 °C. For continuous use, the product may be stored at 2–8 °C for up to one month. For extended storage, freeze in working aliquots at –20 °C. Repeated freezing and thawing is not recommended. Storage in “frost-free” freezers is also not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

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