S9632
Sulconazole nitrate salt
别名:
1-(2-[p-Chlorobenzylthio]-2-[2,4-dichlorophenyl]ethyl)-1H-imidazole
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关于此项目
经验公式（希尔记法）:
C18H15Cl3N2S · HNO3
化学文摘社编号:
分子量:
460.76
UNSPSC Code:
51101500
PubChem Substance ID:
MDL number:
form
powder
color
white
antibiotic activity spectrum
fungi
mode of action
enzyme | inhibits
storage temp.
room temp
SMILES string
O[N+]([O-])=O.Clc1ccc(CSC(Cn2ccnc2)c3ccc(Cl)cc3Cl)cc1
InChI
1S/C18H15Cl3N2S.HNO3/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21;2-1(3)4/h1-9,12,18H,10-11H2;(H,2,3,4)
InChI key
CRKGMGQUHDNAPB-UHFFFAOYSA-N
General description
Chemical structure: imidazole
Application
Sulconazole nitrate is an antifungal medication of the imidazole class. It is used clinically to treat skin infections, such as ringworm, athlete′s foot, jock itch, and sun fungus. It is used to block ergosterol biosynthesis and to inhibit heme oxygenases.
Biochem/physiol Actions
Sulconazole blocks biosynthesis of ergosterol by inhibiting fungal cytochrome P450-dependent lanosterol 14-α-demethylase, a mechanism similar among azoles. Sulconazole is a heme oxygenase (HO) inhibitor. It has been shown to inhibit both HO-1 and HO-2 in vitro.
Other Notes
Keep container tightly closed in a dry and well-ventilated place.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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相关内容
Product Information Sheet
S Dekio et al.
The Journal of dermatology, 17(7), 448-451 (1990-07-01)
A 57-year-old Japanese man with tinea of the scrotum was described. His lesions on the scrotum were unusual; they appeared as lichenified plaques.
María Castro-Puyana et al.
Electrophoresis, 28(15), 2667-2674 (2007-07-04)
The enantioselective separation of a group of six weak base azole compounds was achieved in this work using EKC with three neutral beta-CDs as chiral selectors. The native beta-CD and two other beta-CD derivatives with different types and positions of
Overview of medically important antifungal azole derivatives
Fromtling, RA
Clin. Microbiol. Reviews, 1, 187-217 (1988)