S9632
Sulconazole nitrate salt
别名:
1-(2-[p-Chlorobenzylthio]-2-[2,4-dichlorophenyl]ethyl)-1H-imidazole
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关于此项目
经验公式（希尔记法）:
C18H15Cl3N2S · HNO3
化学文摘社编号:
分子量:
460.76
MDL编号:
UNSPSC代码:
51101500
PubChem化学物质编号:
表单
powder
颜色
white
抗生素抗菌谱
fungi
作用机制
enzyme | inhibits
储存温度
room temp
SMILES字符串
O[N+]([O-])=O.Clc1ccc(CSC(Cn2ccnc2)c3ccc(Cl)cc3Cl)cc1
InChI
1S/C18H15Cl3N2S.HNO3/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21;2-1(3)4/h1-9,12,18H,10-11H2;(H,2,3,4)
InChI key
CRKGMGQUHDNAPB-UHFFFAOYSA-N
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一般描述
Chemical structure: imidazole
应用
Sulconazole nitrate is an antifungal medication of the imidazole class. It is used clinically to treat skin infections, such as ringworm, athlete′s foot, jock itch, and sun fungus. It is used to block ergosterol biosynthesis and to inhibit heme oxygenases.
生化/生理作用
Sulconazole blocks biosynthesis of ergosterol by inhibiting fungal cytochrome P450-dependent lanosterol 14-α-demethylase, a mechanism similar among azoles. Sulconazole is a heme oxygenase (HO) inhibitor. It has been shown to inhibit both HO-1 and HO-2 in vitro.
其他说明
Keep container tightly closed in a dry and well-ventilated place.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
H C Gugnani et al.
Mycoses, 40(3-4), 139-141 (1997-12-31)
A 1% cream of sulconazole nitrate, an imidazole derivative, was used to treat 38 patients with diverse clinical types of dermatomycoses, including 16 cases of pityriasis versicolor, 14 of dermatophytosis (tinea pedis, tinea cruris, tinea corporis), two of balanoposthitis due
Hiroshi Ogura et al.
Biochemistry, 43(46), 14712-14721 (2004-11-17)
The epothilones are a new class of highly promising anticancer agents with a mode of action akin to that of paclitaxel but with distinct advantages over that drug. The principal natural compounds are epothilones A and B, which have an
Hassan Y Aboul-Enein et al.
Journal of pharmaceutical and biomedical analysis, 27(3-4), 441-446 (2002-01-05)
The chiral resolution of (+/-)-econazole, (+/-)-miconazole and (+/-)-sulconazole on the columns containing different cellulose derivatives namely Chiralcel OD, OJ, OB, OK, OC and OF in normal phase mode has been described. The mobile phase used was hexane-2-propanol-diethylamine (425:74:1, v/v/v). The
[Action of sulconazole on fungal membrane].
A Beauvais
Annales de dermatologie et de venereologie, 118 Suppl 1, 13-14 (1991-01-01)
Robert T Kinobe et al.
The Journal of pharmacology and experimental therapeutics, 319(1), 277-284 (2006-06-30)
Ketoconazole (KTZ) and other azole antifungal agents are known to have a variety of actions beyond the inhibition of sterol synthesis in fungi. These drugs share structural features with a series of novel heme oxygenase (HO) inhibitors designed in our
相关内容
Product Information Sheet
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