S9632
Sulconazole nitrate salt
别名:
1-(2-[p-Chlorobenzylthio]-2-[2,4-dichlorophenyl]ethyl)-1H-imidazole
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关于此项目
经验公式（希尔记法）:
C18H15Cl3N2S · HNO3
化学文摘社编号:
分子量:
460.76
UNSPSC Code:
51101500
PubChem Substance ID:
MDL number:
InChI
1S/C18H15Cl3N2S.HNO3/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21;2-1(3)4/h1-9,12,18H,10-11H2;(H,2,3,4)
SMILES string
O[N+]([O-])=O.Clc1ccc(CSC(Cn2ccnc2)c3ccc(Cl)cc3Cl)cc1
InChI key
CRKGMGQUHDNAPB-UHFFFAOYSA-N
form
powder
color
white
antibiotic activity spectrum
fungi
mode of action
enzyme | inhibits
storage temp.
room temp
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General description
Chemical structure: imidazole
Application
Sulconazole nitrate is an antifungal medication of the imidazole class. It is used clinically to treat skin infections, such as ringworm, athlete′s foot, jock itch, and sun fungus. It is used to block ergosterol biosynthesis and to inhibit heme oxygenases.
Biochem/physiol Actions
Sulconazole blocks biosynthesis of ergosterol by inhibiting fungal cytochrome P450-dependent lanosterol 14-α-demethylase, a mechanism similar among azoles. Sulconazole is a heme oxygenase (HO) inhibitor. It has been shown to inhibit both HO-1 and HO-2 in vitro.
Other Notes
Keep container tightly closed in a dry and well-ventilated place.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Molecular properties of econazole and sulconazole relevant to bioavailability.
Monika Grudzień et al.
Acta poloniae pharmaceutica, 63(5), 465-466 (2007-03-16)
[Action of sulconazole on fungal membrane].
A Beauvais
Annales de dermatologie et de venereologie, 118 Suppl 1, 13-14 (1991-01-01)
S Dekio et al.
The Journal of dermatology, 17(7), 448-451 (1990-07-01)
A 57-year-old Japanese man with tinea of the scrotum was described. His lesions on the scrotum were unusual; they appeared as lichenified plaques.
Robert T Kinobe et al.
The Journal of pharmacology and experimental therapeutics, 319(1), 277-284 (2006-06-30)
Ketoconazole (KTZ) and other azole antifungal agents are known to have a variety of actions beyond the inhibition of sterol synthesis in fungi. These drugs share structural features with a series of novel heme oxygenase (HO) inhibitors designed in our
Overview of medically important antifungal azole derivatives
Fromtling, RA
Clin. Microbiol. Reviews, 1, 187-217 (1988)
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