S9632
Sulconazole nitrate salt
别名:
1-(2-[p-Chlorobenzylthio]-2-[2,4-dichlorophenyl]ethyl)-1H-imidazole
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C18H15Cl3N2S · HNO3
化学文摘社编号:
分子量:
460.76
UNSPSC Code:
51101500
PubChem Substance ID:
MDL number:
InChI
1S/C18H15Cl3N2S.HNO3/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21;2-1(3)4/h1-9,12,18H,10-11H2;(H,2,3,4)
SMILES string
O[N+]([O-])=O.Clc1ccc(CSC(Cn2ccnc2)c3ccc(Cl)cc3Cl)cc1
InChI key
CRKGMGQUHDNAPB-UHFFFAOYSA-N
form
powder
color
white
antibiotic activity spectrum
fungi
mode of action
enzyme | inhibits
storage temp.
room temp
正在寻找类似产品? 访问 产品对比指南
General description
Chemical structure: imidazole
Application
Sulconazole nitrate is an antifungal medication of the imidazole class. It is used clinically to treat skin infections, such as ringworm, athlete′s foot, jock itch, and sun fungus. It is used to block ergosterol biosynthesis and to inhibit heme oxygenases.
Biochem/physiol Actions
Sulconazole blocks biosynthesis of ergosterol by inhibiting fungal cytochrome P450-dependent lanosterol 14-α-demethylase, a mechanism similar among azoles. Sulconazole is a heme oxygenase (HO) inhibitor. It has been shown to inhibit both HO-1 and HO-2 in vitro.
Other Notes
Keep container tightly closed in a dry and well-ventilated place.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
H C Gugnani et al.
Mycoses, 40(3-4), 139-141 (1997-12-31)
A 1% cream of sulconazole nitrate, an imidazole derivative, was used to treat 38 patients with diverse clinical types of dermatomycoses, including 16 cases of pityriasis versicolor, 14 of dermatophytosis (tinea pedis, tinea cruris, tinea corporis), two of balanoposthitis due
Hassan Y Aboul-Enein et al.
Journal of pharmaceutical and biomedical analysis, 27(3-4), 441-446 (2002-01-05)
The chiral resolution of (+/-)-econazole, (+/-)-miconazole and (+/-)-sulconazole on the columns containing different cellulose derivatives namely Chiralcel OD, OJ, OB, OK, OC and OF in normal phase mode has been described. The mobile phase used was hexane-2-propanol-diethylamine (425:74:1, v/v/v). The
Molecular properties of econazole and sulconazole relevant to bioavailability.
Monika Grudzień et al.
Acta poloniae pharmaceutica, 63(5), 465-466 (2007-03-16)
[Action of sulconazole on fungal membrane].
A Beauvais
Annales de dermatologie et de venereologie, 118 Suppl 1, 13-14 (1991-01-01)
S Dekio et al.
The Journal of dermatology, 17(7), 448-451 (1990-07-01)
A 57-year-old Japanese man with tinea of the scrotum was described. His lesions on the scrotum were unusual; they appeared as lichenified plaques.
相关内容
Product Information Sheet
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持