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Merck
CN

S9882

磺胺氯哒嗪

别名:

4-氨基- N -(6-氯-3-哒嗪基)苯磺酰胺, N 1 -(6-氯-3-哒嗪基)磺胺

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关于此项目

经验公式(希尔记法):
C10H9ClN4O2S
化学文摘社编号:
分子量:
284.72
UNSPSC Code:
51102829
NACRES:
NA.85
PubChem Substance ID:
EC Number:
201-269-9
Beilstein/REAXYS Number:
261558
MDL number:
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InChI key

XOXHILFPRYWFOD-UHFFFAOYSA-N

InChI

1S/C10H9ClN4O2S/c11-9-5-6-10(14-13-9)15-18(16,17)8-3-1-7(12)2-4-8/h1-6H,12H2,(H,14,15)

SMILES string

Nc1ccc(cc1)S(=O)(=O)Nc2ccc(Cl)nn2

form

powder

color

off-white to light yellow

solubility

0.5 M NaOH: soluble 50 mg/mL

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, mycoplasma

mode of action

DNA synthesis | interferes

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Application

磺胺氯哒嗪是一种磺胺类抗生素,用于研究动力学、反应途径和毒性演变 。磺胺氯哒嗪已被用于治疗儿科患者的急性尿路感染

Biochem/physiol Actions

磺胺氯哒嗪是一种磺胺类抗生素,通过抑制二氢丙酸合成酶来阻断二氢叶酸的合成。磺胺氯哒嗪是细菌对氨基苯甲酸(PABA)的竞争性抑制剂,它是细菌合成叶酸所必需的。它对革兰氏阳性细菌、革兰氏阴性细菌和衣原体均具有抗性。抗性产生机制是通过改变二氢蝶酸合成酶或叶酸合成的替代途径

Other Notes

保存于密闭容器内,置于干燥通风处。

pictograms

Exclamation mark

signalword

Warning

hcodes

pcodes

Hazard Classifications

Skin Sens. 1

存储类别

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Absorption and Excretion of Sulfachloropyridazine
Wilfred F. Jones, Jr, Mohsen Ziai, et al.
Exp. Biol. Med, 95, 642-645 (1957)
[Sulfachloropyridazine in the treatment of acute infections of the urinary tract in childhood].
R C PEDRINAZZI et al.
Minerva pediatrica, 12, 1342-1347 (1960-10-27)
Thomas L ter Laak et al.
Environmental toxicology and chemistry, 25(4), 904-911 (2006-04-25)
Antimicrobial agents are the most heavily used pharmaceuticals in intensive husbandry. Their usual discharge pathway is application to agricultural land as constituents of animal manure, which is used as fertilizer. Many of these compounds undergo pH-dependent speciation and, therefore, might
Paul A Blackwell et al.
Chemosphere, 67(2), 292-299 (2007-01-06)
The environmental fate of the antibiotics sulfachloropyridazine and oxytetracycline was investigated in a sandy loam soil. Liquid pig manure was fortified with the compounds and then applied to soil plots to investigate leaching, dissipation and surface run-off under field conditions.
Paul Kay et al.
Environmental toxicology and chemistry, 23(5), 1136-1144 (2004-06-08)
The environment may be exposed to veterinary medicines administered to livestock through the application of organic fertilizers to land. For other groups of substances that are applied to agricultural land (e.g., pesticides), preferential flow in underdrained clay soils has been

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