S9882
磺胺氯哒嗪
别名:
4-氨基- N -（6-氯-3-哒嗪基）苯磺酰胺, N 1 -（6-氯-3-哒嗪基）磺胺
表单
powder
颜色
off-white to light yellow
溶解性
0.5 M NaOH: soluble 50 mg/mL
抗生素抗菌谱
Gram-negative bacteria
Gram-positive bacteria
mycoplasma
作用机制
DNA synthesis | interferes
SMILES字符串
Nc1ccc(cc1)S(=O)(=O)Nc2ccc(Cl)nn2
InChI
1S/C10H9ClN4O2S/c11-9-5-6-10(14-13-9)15-18(16,17)8-3-1-7(12)2-4-8/h1-6H,12H2,(H,14,15)
InChI key
XOXHILFPRYWFOD-UHFFFAOYSA-N
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应用
磺胺氯哒嗪是一种磺胺类抗生素，用于研究动力学、反应途径和毒性演变 。磺胺氯哒嗪已被用于治疗儿科患者的急性尿路感染 。
生化/生理作用
磺胺氯哒嗪是一种磺胺类抗生素，通过抑制二氢丙酸合成酶来阻断二氢叶酸的合成。磺胺氯哒嗪是细菌对氨基苯甲酸（PABA）的竞争性抑制剂，它是细菌合成叶酸所必需的。它对革兰氏阳性细菌、革兰氏阴性细菌和衣原体均具有抗性。抗性产生机制是通过改变二氢蝶酸合成酶或叶酸合成的替代途径。
其他说明
保存于密闭容器内，置于干燥通风处。
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Antibiotics may be released to soils during the application of manure as fertiliser to land. The compounds may subsequently be transported to and contaminate groundwater and surface waters. This paper describes a series of lysimeter-based studies to explore the leaching
E van Duijkeren et al.
Journal of veterinary pharmacology and therapeutics, 18(1), 47-53 (1995-02-01)
In the present study, the pharmacokinetic parameters of a trimethoprim/sulphachlorpyridazine preparation following intravenous administration, administration by nasogastric tube and administration with concentrate were determined in the horse. Eight adult horses were dosed at 1 week intervals in a sequentially designed
Paul Kay et al.
Environmental pollution (Barking, Essex : 1987), 134(2), 333-341 (2004-12-14)
Pharmaceuticals used in livestock production may be present in manure and slurry as the parent compound and/or metabolites. The environment may therefore be exposed to these substances due to the application of organic fertilisers to agricultural land or deposition by
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