S9882
磺胺氯哒嗪
别名:
4-氨基- N -（6-氯-3-哒嗪基）苯磺酰胺, N 1 -（6-氯-3-哒嗪基）磺胺
表单
powder
颜色
off-white to light yellow
溶解性
0.5 M NaOH: soluble 50 mg/mL
抗生素抗菌谱
Gram-negative bacteria
Gram-positive bacteria
mycoplasma
作用机制
DNA synthesis | interferes
SMILES字符串
Nc1ccc(cc1)S(=O)(=O)Nc2ccc(Cl)nn2
InChI
1S/C10H9ClN4O2S/c11-9-5-6-10(14-13-9)15-18(16,17)8-3-1-7(12)2-4-8/h1-6H,12H2,(H,14,15)
InChI key
XOXHILFPRYWFOD-UHFFFAOYSA-N
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应用
磺胺氯哒嗪是一种磺胺类抗生素，用于研究动力学、反应途径和毒性演变 。磺胺氯哒嗪已被用于治疗儿科患者的急性尿路感染 。
生化/生理作用
磺胺氯哒嗪是一种磺胺类抗生素，通过抑制二氢丙酸合成酶来阻断二氢叶酸的合成。磺胺氯哒嗪是细菌对氨基苯甲酸（PABA）的竞争性抑制剂，它是细菌合成叶酸所必需的。它对革兰氏阳性细菌、革兰氏阴性细菌和衣原体均具有抗性。抗性产生机制是通过改变二氢蝶酸合成酶或叶酸合成的替代途径。
其他说明
保存于密闭容器内，置于干燥通风处。
Paul Kay et al.
Environmental toxicology and chemistry, 23(5), 1136-1144 (2004-06-08)
The environment may be exposed to veterinary medicines administered to livestock through the application of organic fertilizers to land. For other groups of substances that are applied to agricultural land (e.g., pesticides), preferential flow in underdrained clay soils has been
Thomas L ter Laak et al.
Environmental toxicology and chemistry, 25(4), 904-911 (2006-04-25)
Antimicrobial agents are the most heavily used pharmaceuticals in intensive husbandry. Their usual discharge pathway is application to agricultural land as constituents of animal manure, which is used as fertilizer. Many of these compounds undergo pH-dependent speciation and, therefore, might
Heike Schmitt et al.
Environmental science & technology, 38(4), 1148-1153 (2004-03-05)
Little is known about the environmental hazards linked to the treatment of farm animals with antibiotics and subsequent spreading of manure, especially regarding soil microbial communities. In this investigation, pollution-induced community tolerance (PICT) of bacteria from soils artificially spiked with
Thomas L ter Laak et al.
Environmental toxicology and chemistry, 25(4), 933-941 (2006-04-25)
Environmental exposure assessment of veterinary pharmaceuticals requires estimating the sorption to soil. Soil sorption coefficients of three common, ionizable, antimicrobial agents (oxytetracycline [OTC], tylosin [TYL], and sulfachloropyridazine [SCP]) were studied in relation to the soil properties of 11 different soils.
Ahmad Dirany et al.
Environmental science & technology, 46(7), 4074-4082 (2012-02-16)
The electro-Fenton treatment of sulfachloropyridazine (SCP), a model for sulfonamide antibiotics that are widespread in waters, was performed using cells with a carbon-felt cathode and Pt or boron-doped diamond (BDD) anode, aiming to present an integral assessment of the kinetics
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