S9882
磺胺氯哒嗪
别名:
4-氨基- N -（6-氯-3-哒嗪基）苯磺酰胺, N 1 -（6-氯-3-哒嗪基）磺胺
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经验公式（希尔记法）:
C10H9ClN4O2S
化学文摘社编号:
分子量:
284.72
UNSPSC Code:
51102829
NACRES:
NA.85
PubChem Substance ID:
EC Number:
201-269-9
Beilstein/REAXYS Number:
261558
MDL number:
InChI key
XOXHILFPRYWFOD-UHFFFAOYSA-N
InChI
1S/C10H9ClN4O2S/c11-9-5-6-10(14-13-9)15-18(16,17)8-3-1-7(12)2-4-8/h1-6H,12H2,(H,14,15)
SMILES string
Nc1ccc(cc1)S(=O)(=O)Nc2ccc(Cl)nn2
form
powder
color
off-white to light yellow
solubility
0.5 M NaOH: soluble 50 mg/mL
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria, mycoplasma
mode of action
DNA synthesis | interferes
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Application
磺胺氯哒嗪是一种磺胺类抗生素，用于研究动力学、反应途径和毒性演变 。磺胺氯哒嗪已被用于治疗儿科患者的急性尿路感染 。
Biochem/physiol Actions
磺胺氯哒嗪是一种磺胺类抗生素，通过抑制二氢丙酸合成酶来阻断二氢叶酸的合成。磺胺氯哒嗪是细菌对氨基苯甲酸（PABA）的竞争性抑制剂，它是细菌合成叶酸所必需的。它对革兰氏阳性细菌、革兰氏阴性细菌和衣原体均具有抗性。抗性产生机制是通过改变二氢蝶酸合成酶或叶酸合成的替代途径。
Other Notes
保存于密闭容器内，置于干燥通风处。
[Sulfachloropyridazine in the treatment of acute infections of the urinary tract in childhood].
R C PEDRINAZZI et al.
Minerva pediatrica, 12, 1342-1347 (1960-10-27)
Absorption and Excretion of Sulfachloropyridazine
Wilfred F. Jones, Jr, Mohsen Ziai, et al.
Exp. Biol. Med, 95, 642-645 (1957)
E van Duijkeren et al.
The Veterinary record, 137(19), 483-486 (1995-11-04)
The pharmacokinetic parameters of a powder formulation of trimethoprim/sulphachlorpyridazine were studied in eight healthy horses which received 5 mg/kg trimethoprim and 25 mg/kg sulphachlorpyridazine 12-hourly with concentrate for five days. The intake of the medicated concentrate by the horses was
E Van Duijkeren et al.
Journal of veterinary pharmacology and therapeutics, 19(4), 281-287 (1996-08-01)
Binding of antibiotics to food has received little attention in equine medicine, although such binding could potentially reduce the bioavailability and clinical efficacy. In the present study, binding of trimethoprim (TMP) and sulphachlorpyridazine (SCP) to hay, grass silage and concentrate
Thomas L ter Laak et al.
Environmental toxicology and chemistry, 25(4), 933-941 (2006-04-25)
Environmental exposure assessment of veterinary pharmaceuticals requires estimating the sorption to soil. Soil sorption coefficients of three common, ionizable, antimicrobial agents (oxytetracycline [OTC], tylosin [TYL], and sulfachloropyridazine [SCP]) were studied in relation to the soil properties of 11 different soils.
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