SAB1300127
Anti-PACSIN2 (C-term) antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
别名:
Anti-Protein kinase C and casein kinase substrate in neurons protein 2
产品名称
Anti-PACSIN2 (C-term) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
mouse, human
technique(s)
immunohistochemistry: 1:50-1:100
indirect ELISA: 1:1000
indirect immunofluorescence: 1:10-1:50
western blot: 1:100-1:500
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PACSIN2(11252)
Application
Anti-PACSIN2 (C-term) antibody produced in rabbit has been used in immunostaining.
Biochem/physiol Actions
Protein kinase C and casein kinase substrate in neurons 2 (PACSIN2) may play a role in vesicle formation and transport and organization of cytoskeleton. This protein homo- and hetero-aggregates with other PACSINs and thus acts as membrane associated adapter protein. It also binds dynamin 1, synaptojanin, synapsin 1 and the neural Wiskott-Aldrich syndrome protein (N-WASP). Pacsin2 is crucial for the formation and maintenance of kidney associated tubules. Pacsin2 is involved with caveolae biogenesis in plasma membrane. Pacsin2 regulates cell migration and spreading by binding with Rac1 (Ras-related C3 botulinum toxin substrate 1) protein. Pacsin2 is involved in microspike formation and tubulation like filopodia, lamellopodia in the cell.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Protein kinase C and casein kinase substrate in neurons 2 (PACSIN2), also termed syndapin II exhibits a vesicle-like cytoplasmic distribution and is ubiquitously expressed. PACSIN is phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC). The protein contains EFC/F-BAR (Fes/CIP4 homology - Bin/amphiphysin/Rvs ) domain (1 FCH domain) and 1 SH3 (Src homology 3) domain. In human chromosome, the gene PACSIN2 is localized on 22q13.2.
Immunogen
PACSIN2 (NP_009160, 347-381)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human PACSIN2.
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human PACSIN2.
Physical form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Novel activating BRAF fusion identifies a recurrent alternative mechanism for ERK activation in pediatric Langerhans cell histiocytosis
Zarnegar S, et al.
Pediatric Blood & Cancer, 65(1), e26699-e26699 (2018)
Mapping of the basic amino-acid residues responsible for tubulation and cellular protrusion by the EFC/F-BAR domain of pacsin2/Syndapin II
Shimada A, et al.
Febs Letters, 584(6), 1111-1118 (2010)
Pacsin 2 is recruited to caveolae and functions in caveolar biogenesis
Hansen CG, et al.
Journal of Cell Science, 124(16), 2777-2785 (2011)
Live imaging of prions reveals nascent PrPSc in cell-surface, raft-associated amyloid strings and webs
Rouvinski A, et al.
The Journal of Cell Biology, 204(3), 423-441 (2014)
The F-BAR domain protein PACSIN2 associates with Rac1 and regulates cell spreading and migration
de Kreuk BJ, et al.
Journal of Cell Science, jcs-080630 (2011)
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