SAB1300167
Anti-Cbl (C-term) antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
别名:
Anti-CBLC, Anti-RING finger protein 57, Anti-RNF57, Anti-Signal transduction protein CBL-C, SH3-binding protein CBL-C, CBL-3
生物来源
rabbit
偶联物
unconjugated
抗体形式
IgG fraction of antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
种属反应性
human
技术
immunohistochemistry: 1:50-1:100
indirect ELISA: 1:1000
western blot: 1:100-1:500
NCBI登记号
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... CBLC(23624)
一般描述
Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl- c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.
免疫原
CBL (NP_036248, 429-463)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human Cbl-c.
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human Cbl-c.
外形
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
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储存分类代码
10 - Combustible liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
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