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SAB1300276

Anti-ARL2 (N-term) antibody produced in rabbit

Name: Anti-ARL2 (N-term) antibody produced in rabbit
Brand: SIGMA

IgG fraction of antiserum, buffered aqueous solution

别名:

Anti-ADP-ribosylation factor-like protein 2, Anti-ARL2

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关于此项目

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ELISA (i), WB

Citations:

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属性

biological source

rabbit

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

indirect ELISA: 1:1000, western blot: 1:100-1:500

NCBI accession no.

NP_001658

UniProt accession no.

P36404

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ARL2(402)

说明

General description

ADP-ribosylation factors (ARFs) regulate intracellular vesicular membrane trafficking and stimulate a phospholipase D isoform. ARL (ADP-ribosylation like factor) proteins are very similar in sequence to ARFs. ARFs and ARF-like (ARL) proteins, which share sequence similarity with ARFs, form a subfamily of the Ras-related GTPase superfamily. ARL2 encodes a ubiquitiously expressed 184-amino acid predicted protein that is 76% identical to ARF1 and 40 to 45% identical to the Drosophila ARL proteins. Recombinant ARL2 binds to GTP rapidly but guanine nucleotide exchange does not require phospholipids, which is a characteristic of the ARF proteins.

Immunogen

ARL2 (NP_001658, 1-30)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human ARL2.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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存储类别

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

常规特殊物品

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

020M1638

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Whole-exome sequencing identified ARL2 as a novel candidate gene for MRCS (microcornea, rod-cone dystrophy, cataract, and posterior staphyloma) syndrome.

Xue-Bi Cai et al.

Clinical genetics, 96(1), 61-71 (2019-04-05)

Adenosine diphosphate (ADP)-ribosylation factor-like 2 (ARL2) protein participates in a broad range of cellular processes and acts as a mediator for mutant ARL2BP in cilium-associated retinitis pigmentosa and for mutant HRG4 in mitochondria-related photoreceptor degeneration. However, mutant ARL2 has not