SAB1300308
Anti-GPC4 (N-term) antibody produced in rabbit
saturated ammonium sulfate (SAS) precipitated, buffered aqueous solution
别名:
Anti-GPC4, Anti-Glypican-4, Anti-K-glypican, Anti-Secreted glypican-4
生物来源
rabbit
偶联物
unconjugated
抗体形式
saturated ammonium sulfate (SAS) precipitated
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
种属反应性
human
技术
immunohistochemistry: 1:50-1:100
indirect ELISA: 1:1000
NCBI登记号
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... GPC4(2239)
一般描述
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent to the 3′ end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome.
GPC4 (glypican-4) gene is mapped to human chromosome Xq26.2. The encoded protein is a heparan sulfate proteoglycan and localizes to membrane microdomains.
免疫原
GPC4 (NP_001439, 30-66)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-term region of human GPC4.
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-term region of human GPC4.
生化/生理作用
GPC4 (glypican-4) is associated with a number of signaling mechanisms involving growth factors. GPC4 influences cell proliferation, by serving as a co-receptor for growth factors. It regulates the Wnt signaling pathway. GPC4 might be associated with epileptic seizures, with this gene upregulated in the brain. GPC4 is an adipokine and is known to enhance insulin signaling and regulate adipocyte differentiation. Overexpression of this gene in polycystic ovary syndrome might be associated with the risk of cardiovascular disease.
外形
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
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储存分类代码
10 - Combustible liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Yan Xiong et al.
Biochemical and biophysical research communications, 478(1), 241-246 (2016-07-19)
Glypican-4 (Gpc4) has been found to play an important role in enhancing miniature excitatory postsynaptic currents (mEPSCs). But, the relationship between Gpc4 and epilepsy is still a mystery. In this study, we investigated the expression patterns of Gpc4 in patients
H J Yoo et al.
The Journal of clinical endocrinology and metabolism, 98(7), 2897-2901 (2013-05-02)
Glypican-4 was identified as a novel adipokine capable of enhancing insulin signaling and modulating adipocyte differentiation. We investigated associations between glypican-4 and body composition, insulin resistance, arterial stiffness, and nonalcoholic fatty liver disease (NAFLD) in nondiabetic Asian subjects. We analyzed
Chao Feng et al.
Glycoconjugate journal, 29(7), 503-511 (2012-05-31)
Heparan sulfate proteoglycan (HSPG), such as glypican, plays a role as a co-receptor for growth factor to influence cells proliferation. However the mechanism is still vague. Micro-RNAs (miRNAs) regulate cell proliferation. Their capacity to direct the translation and stability of
Diana Jędrzejuk et al.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 32(3), 223-226 (2015-10-22)
Glypican-4 (Gpc4) is an adipokine which interacts with the insulin receptor and affects insulin sensitivity in proteoglycans. Insulin resistance plays a crucial role in the etiology of polycystic ovary syndrome (PCOS). PCOS is associated with metabolic disturbances such as abdominal
Chih-Ping Chen
Taiwanese journal of obstetrics & gynecology, 51(2), 186-191 (2012-07-17)
With the advent of prenatal sonography, fetal overgrowth can be easily detected. Prenatal-onset overgrowth can be secondary to normal variants of familial tall stature, familial rapid maturation, diabetic macrosomia, and congenital nesidioblastosis, or prenatal-onset overgrowth can be primary due to
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