SAB1300919
Anti-PHLPP2 (N-term) antibody produced in rabbit
saturated ammonium sulfate (SAS) precipitated, buffered aqueous solution
别名:
Anti-KIAA0931, Anti-PH domain leucine-rich repeat protein phosphatase-like, Anti-PHLPP-like, Anti-PHLPP2, Anti-PHLPPL
生物来源
rabbit
偶联物
unconjugated
抗体形式
saturated ammonium sulfate (SAS) precipitated
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
种属反应性
human
技术
immunohistochemistry: 1:50-1:100
indirect ELISA: 1:1000
NCBI登记号
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... PHLPP2(23035)
一般描述
The PH domain and leucine rich repeat protein phosphatase 2 (PHLPP2) gene with 18 exons, is mapped to human chromosome 16q22.2. The encoded protein is a isoform of PHLPP family and is composed of 1323 amino acids. PHLPP2 is characterized with a pleckstrin homology domain (PH domain), leucine-rich repeats, a protein phosphatase 2C (PP2C) domain and a PDZ-binding motif.
免疫原
PHLPP2 (NP_055835, 9-42)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-term region of human PHLPP2.
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-term region of human PHLPP2.
应用
Anti-PHLPP2 (N-term) antibody produced in rabbit has been used in immunoblotting.
生化/生理作用
PH domain and leucine rich repeat protein phosphatase 2 (PHLPP2) is a tumor suppressor. It plays a vital role in cell survival by inactivating Akt, inhibiting cell-cycle progression and stimulating apoptosis. Expression of PHLPP protein is decreased in hypopharyngeal squamous cell carcinomas (HSCCs). Thus, this protein can be used as a marker to determine the poor prognosis in HSCCs patients.
外形
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
此项目有
PHLPP2 down regulation influences nuclear Nrf2 stability via Akt-1/Gsk3?/Fyn kinase axis in acetaminophen induced oxidative renal toxicity: Protection accorded by morin.
Mathur A
Food And Chemical Toxicology, 89, 19-31 (2016)
Fatima Rizvi et al.
Redox biology, 6, 587-598 (2015-10-30)
Recent advances indicate a possible role of phytochemicals as modulatory factors in signaling pathways. We have previously demonstrated PHLPP2-mediated suppression of Nrf2 responses during oxidant attack. The present study was designed to explore Nrf2-potentiating mechanism of morin, a flavonol, via
Haiyan Xing et al.
Frontiers in pharmacology, 11, 1065-1065 (2020-08-09)
Hyperoside, isolated from Drosera rotundifolia L., seeds of Cuscuta chinensis Lam., or Hypericum perforatum L., originally showed to possess an antifungal and antibacterial activity, while recently showed the protective effects against oxidative stress-induced liver injury. This study investigated such a
PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms.
Brognard J
Molecular Cell, 25(6), 917-931 (2007)
Aberrant expression of PHLPP1 and PHLPP2 correlates with poor prognosis in patients with hypopharyngeal squamous cell carcinoma.
Zhou J
PLoS ONE, 10 (2015)
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