Anti-CYP17A1 (center) antibody produced in rabbit

Cytochrome P450 family 17 subfamily A member 1 (CYP17A1) is a member of the cytochrome P450 superfamily of enzymes. It is encoded by the gene mapped to human chromosome 10q24.32. This protein localizes to the endoplasmic reticulum.

CYP17A1 (NP_000093, 363-398)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the Center region of human CYP17A1.

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Cytochrome P450 family 17 subfamily A member 1 (CYP17A1) catalyzes 17Α-hydroxylation of steroid substrates and cleavage and oxidation of their side-chains. It has both 17Α-hydroxylase and 17, 20-lyase activities. The protein acts as a key enzyme in the synthesis of cortisol, testosterone and oestrogen. Mutations in CYP17A1 gene are associated with mineralocorticoid excess syndromes, glucocorticoid and sex hormone deficiencies. In addition, it also increases the risk of susceptibility to prostate cancer, benign prostatic hypertrophy and occasional congenital adrenal hyperplasia (CAH). Abiraterone inhibits steroidogenic activity of CYP17A1 and retards tumor growth in castration-resistant prostate cancer (CRPC) patients.

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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