SAB1304574
ANTI-TET2 (N-TERM) antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
别名:
KIAA1546, Probable methylcytosine dioxygenase TET2, TET2
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
5
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
223811 Da
species reactivity
human
technique(s)
western blot: 1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... TET2(54790)
General description
Tet methyl cytosine dioxygenase 2 (TET2), a TET oncogene family member 2/ten-eleven translocation 2, is a tumour suppressor gene which encodes a DNA demethylase enzyme. In human chromosome, the gene TET2 is localized on 4q24.
Biochem/physiol Actions
Tet methyl cytosine dioxygenase 2 (TET2) catalyses the conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in DNA. TET2 is essential for normal myelopoiesis, epigenetic programming, embryonic stem cell maintenance and early development. Mutations in TET2 leads to myelodysplastic syndromes (MDS), myeloproliferative disorder, myeloproliferative neoplasms (MPN). Mutations also causes different leukaemia like chronic myelomonocytic leukaemia (CMML), acute myeloid leukaemias (AML), secondary AML (sAML) and myeloid malignancies. TET2 regulates mast cell differentiation and proliferation and cytokine production.
Physical form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
此项目有
Mutation in TET2 in myeloid cancers
Delhommeau F, et al.
The New England Journal of Medicine, 360(22), 2289-2301 (2009)
TET2 regulates mast cell differentiation and proliferation through catalytic and non-catalytic activities
Montagner S, et al.
Cell Reports, 15(7), 1566-1579 (2016)
The role of TET2 in hematologic neoplasms
Holmfeldt L and Mullighan CG
Cancer Cell, 20(1), 1-2 (2011)
Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2
Ko M, et al.
Nature, 468(7325), 839-839 (2010)
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
Figueroa ME, et al.
Cancer Cell, 18(6), 553-567 (2010)
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