SAB1305554
Anti-β-Actin (ACTB) Antibody
mouse monoclonal, 137CT26.1.1
别名:
ACTB, Actin, cytoplasmic 1, Actin, cytoplasmic 1, N-terminally processed, Beta-actin
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
Clone:
137CT26.1.1, monoclonal
Species reactivity:
mouse, human
Application:
IF, IHC, WB
Citations:
14
产品名称
MONOCLONAL ANTI-BETA-ACTIN antibody produced in mouse, clone 137CT26.1.1, IgG fraction of antiserum, buffered aqueous solution
biological source
mouse
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
137CT26.1.1, monoclonal
form
buffered aqueous solution
mol wt
41737 Da
species reactivity
mouse, human
technique(s)
immunofluorescence: 1:10-1:50, immunohistochemistry: 1:25, western blot: 1:1000
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ACTB(60)
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General description
β-actin (ACTB), a member of the actin multigene family, is an isoform of actin-associated with non-muscle cells. ACTB is a housekeeping gene mapped to human chromosome 7p22.1.
Application
Monoclonal Anti-Beta-Actin antibody produced in mouse has been used in western blotting at a dilution of 1:1000.
Biochem/physiol Actions
β-actin (ACTB) forms the core of the cell cytoskeleton. The polymerization of β-actin is essential for cell physiology. It may serve as a potential chemotherapeutic agent. Mutation in the ACTB gene is implicated in sensory hearing loss, delayed-onset generalized dystonia and a combination of ventral midline malformations. A loss-of-function mutation in the ACTB gene may cause intellectual disability.
Physical form
Supplied in PBS with 0.09% (W/V) sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
Sara Cuvertino et al.
American journal of human genetics, 101(6), 1021-1033 (2017-12-09)
ACTB encodes β-actin, an abundant cytoskeletal housekeeping protein. In humans, postulated gain-of-function missense mutations cause Baraitser-Winter syndrome (BRWS), characterized by intellectual disability, cortical malformations, coloboma, sensorineural deafness, and typical facial features. To date, the consequences of loss-of-function ACTB mutations have
Induction of drug resistance in human hepatoma cells cultured on a silicate fiber based 3d scaffold
Mizutami T, et al.
Advances in Biochemical Engineering null
Ioannis Panagopoulos et al.
Anticancer research, 40(3), 1239-1245 (2020-03-07)
Since the first description of five pericytomas with the t(7;12)/ACTB-GLI1 fusion gene, only three new tumors were studied by both cytogenetics and molecular techniques. We report here genetic data on another case of this rare tumor. Cytogenetic, fluorescence in situ
Sequence and structural analysis of beta-actin protein of fishes, using bioinformatics tools and techniques
Acharya UR, et al.
International journal of biosciences, 4(11) (2014)
Immacolata Andolfo et al.
Blood advances, 7(12), 2681-2693 (2023-01-04)
Gain-of-function mutations in PIEZO1 cause dehydrated hereditary stomatocytosis (DHS) or hereditary xerocytosis, an autosomal dominant hemolytic anemia characterized by high reticulocyte count, a tendency to macrocytosis, and mild jaundice, as well as by other variably penetrant clinical features, such as
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