SAB1306806
ANTI-MSL1 (CENTER) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
别名:
MSL1, MSL1L1, Male-specific lethal 1 homolog, Male-specific lethal 1-like 1, Male-specific lethal-1 homolog 1
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Clone:
polyclonal
Species reactivity:
human
Application:
WB
Citations:
2
biological source
rabbit
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
67128 Da
species reactivity
human
technique(s)
western blot: 1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... MSL1(339287)
General description
The gene MSL1 (male specific lethal 1 homolog) encodes a histone acetyl transferase-associated protein that spans a length of 614 amino acid residues. It does not contain any globular domains.
Biochem/physiol Actions
The gene MSL1 (male specific lethal 1 homolog) encodes a protein associated with mammalian MOF (male-absent-on-the-first)-MSL (male-specific-lethal) complex that is also referred to as the ‘dosage compensation complex′ (DCC). This complex is involved in the equalization of X-chromosomal genes expression between males and females. It is found to form a complex with Nupr1 (nuclear protein 1) in the nucleus in response to DNA-damage and may be involved in DNA repair activity. MSL1 protein is found to regulate acetylation of global histone H4 via its interaction with KAT8 (lysine acetyltransferase 8).
Physical form
Supplied in PBS with 0.09% (W/V) sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
David Aguado-Llera et al.
PloS one, 8(10), e78101-e78101 (2013-11-10)
The stress protein Nupr1 is a highly basic, multifunctional, intrinsically disordered protein (IDP). MSL1 is a histone acetyl transferase-associated protein, known to intervene in the dosage compensation complex (DCC). In this work, we show that both Nupr1 and MSL1 proteins
Ruslan I Dmitriev et al.
Journal of cellular biochemistry, 115(11), 1967-1973 (2014-06-11)
MSL1 protein regulates global histone H4 acetylation at residue K16 in stem and cancer cells, through interaction with KAT8. The functional significance of mammalian MSL1 isoforms, involved in various protein interactions, is poorly understood. We report the identification of a
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