SAB1405800
Anti-Fas Antibody
mouse polyclonal
别名:
CD64, CD64A, FCRI, FLJ18345, IGFR1
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
4
产品名称
Anti-FCGR1A antibody produced in mouse, purified immunoglobulin, buffered aqueous solution
Quality Level
Gene Information
human ... FCGR1A(2209)
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~42.6 kDa
species reactivity
human
technique(s)
western blot: 1 μg/mL
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
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General description
Fc fragment of IgG receptor Ia (FCGR1A) gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. (provided by RefSeq). Fc fragment of IgG receptor Ia (FCGR1A) gene is located on human chromosome 1q21.2. FCGR1A is expressed on monocytes and macrophages.
Immunogen
FCGR1A (NP_000557.1, 1 a.a. ~ 374 a.a) full-length human protein.
Sequence
MWFLTTLLLWVPVDGQVDTTKAVITLQPPWVSVFQEETVTLHCEVLHLPGSSSTQWFLNGTATQTSTPSYRITSASVNDSGEYRCQRGLSGRSDPIQLEIHRGWLLLQVSSRVFTEGEPLALRCHAWKDKLVYNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSGMGKHRYTSAGISVTVKELFPAPVLNASVTSPLLEGNLVTLSCETKLLLQRPGLQLYFSFYMGSKTLRGRNTSSEYQILTARREDSGLYWCEAATEDGNVLKRSPELELQVLGLQLPTPVWFHVLFYLAVGIMFLVNTVLWVTIRKELKRKKKWDLEISLDSGHEKKVISSLQEDRHLEEELKCQEQKEEQLQEGVHRKEPQGAT
Sequence
MWFLTTLLLWVPVDGQVDTTKAVITLQPPWVSVFQEETVTLHCEVLHLPGSSSTQWFLNGTATQTSTPSYRITSASVNDSGEYRCQRGLSGRSDPIQLEIHRGWLLLQVSSRVFTEGEPLALRCHAWKDKLVYNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSGMGKHRYTSAGISVTVKELFPAPVLNASVTSPLLEGNLVTLSCETKLLLQRPGLQLYFSFYMGSKTLRGRNTSSEYQILTARREDSGLYWCEAATEDGNVLKRSPELELQVLGLQLPTPVWFHVLFYLAVGIMFLVNTVLWVTIRKELKRKKKWDLEISLDSGHEKKVISSLQEDRHLEEELKCQEQKEEQLQEGVHRKEPQGAT
Biochem/physiol Actions
Fc fragment of IgG receptor Ia (FCGR1A) functions as the single high-affinity receptor of immunoglobulin G (IgG) in humans. It also regulates immune inflammation. FCGR1A acts as a diagnostic marker for bacterial infections, such as neonatal sepsis. FCGR1A is an important biomarker for rheumatoid arthritis (RA).
Physical form
Solution in phosphate buffered saline, pH 7.4
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Elevated membrane and soluble CD64: a novel marker reflecting altered FcγR function and disease in early rheumatoid arthritis that can be regulated by anti-rheumatic treatment
Matt P, et al.
PLoS ONE, 10(9), e0137474-e0137474 (2015)
Identification of human specific gene duplications relative to other primates by array CGH and quantitative PCR
Armengol G, et al.
Genomics, 95(4) (2010)
FcγRI (CD64) contributes to the severity of immune inflammation through regulating NF-κB/NLRP3 inflammasome pathway
Zhang H, et al.
Life Sciences (2018)
Neutrophil CD64 as a diagnostic marker for neonatal sepsis: Meta-analysis.
Dai J, et al.
Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University (2017)
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