产品名称
Anti-KCNMB4 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~23.9 kDa
species reactivity
human
technique(s)
western blot: 1 μg/mL
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... KCNMB4(27345)
Biochem/physiol Actions
Potassium calcium activated channel subfamily M regulatory α subunit 4 (KCNMB4) plays a vital role in increasing Ca2+ sensitivity. It reduces the voltage dependence of the conductance-voltage relationship as well as the slope of the gating charge-voltage curve.
General description
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit. (provided by RefSeq)
Potassium calcium activated channel subfamily M regulatory β subunit 4 (KCNMB4) is mapped to human chromosome 12q14.1-15. The encoded protein is a member of the potassium channel β subunit family. KCNMB4 contains two transmembrane segments (TM1 and TM2), intracellular N and C terminal and a large extracellular loop. It is mainly expressed in the brain, neuronal tissue, kidney and bladder smooth muscle.
Immunogen
KCNMB4 (NP_055320.4, 1 a.a. ~ 210 a.a) full-length human protein.
Sequence
MAKLRVAYEYTEAEDKSIRLGLFLIISGVVSLFIFGFCWLSPALQDLQATEANCTVLSVQQIGEVFECTFTCGADCRGTSQYPCVQVYVNNSESNSRALLHSDEHQLLTNPKCSYIPPCKRENQKNLESVMNWQQYWKDEIGSQPFTCYFNQHQRPDDVLLHRTHDEIVLLHCFLWPLVTFVVGVLIVVLTICAKSLAVKAEAMKKRKFS
Sequence
MAKLRVAYEYTEAEDKSIRLGLFLIISGVVSLFIFGFCWLSPALQDLQATEANCTVLSVQQIGEVFECTFTCGADCRGTSQYPCVQVYVNNSESNSRALLHSDEHQLLTNPKCSYIPPCKRENQKNLESVMNWQQYWKDEIGSQPFTCYFNQHQRPDDVLLHRTHDEIVLLHCFLWPLVTFVVGVLIVVLTICAKSLAVKAEAMKKRKFS
Physical form
Solution in phosphate buffered saline, pH 7.4
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
hKCNMB3 and hKCNMB4, cloning and characterization of two members of the large?conductance calcium?activated potassium channel β subunit family
Behrens R, et al.
Febs Letters, 474(1), 99-106 (2000)
Pharmacological consequences of the coexpression of BK channel α and auxiliary β subunits
Torres YP, et al.
Frontiers in Physiology, 5, 383-383 (2014)
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