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Merck
CN

SAB1407456

Sigma-Aldrich

Anti-CRBN antibody produced in mouse

purified immunoglobulin, buffered aqueous solution

别名:

CRBN Antibody - Anti-CRBN antibody produced in mouse, Cereblon Antibody, Crbn Antibody, DKFZp781K0715, MGC27358, MRT2A

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关于此项目

UNSPSC代码:
12352203
NACRES:
NA.41
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生物来源

mouse

偶联物

unconjugated

抗体形式

purified immunoglobulin

抗体产品类型

primary antibodies

克隆

polyclonal

表单

buffered aqueous solution

分子量

antigen ~50.5 kDa

种属反应性

human

技术

western blot: 1 μg/mL

NCBI登记号

UniProt登记号

运输

dry ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... CRBN(51185)

一般描述

Cereblon (CRBN) is encoded by the gene mapped to human chromosome 3p26.2. It is ubiquitously expressed in various subcellular compartments such as nucleus, cytoplasm and endoplasmic reticulum (ER).

免疫原

CRBN (NP_057386.2, 1 a.a. ~ 442 a.a) full-length human protein.

Sequence
MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL

应用

Anti-CRBN antibody produced in mouse has been used in western blotting.

生化/生理作用

Cereblon (CRBN) is a substrate binding component of the E3 ubiquitin ligase complex. It interacts with thalidomide and its analog to facilitate proteasome-dependent degradation of the transcription factors, Ikaros family zinc finger protein 1 and 3 (IKZF1 and IKZF3). CRBN provides cytoprotection against the ubiquitin-proteasome system-dysfunction. It negatively regulates the AMP-activated protein kinase signaling pathway in vivo. Nonsense mutation of the CRBN gene causes mild type of autosomal recessive nonsyndromic intellectual disability (ID).

外形

Solution in phosphate buffered saline, pH 7.4

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number

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Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide
Lopez-Girona AEA, et al.
Leukemia Lymphoma, 26(11), 2326-2335 (2012)
Immunomodulatory drugs inhibit TLR4-induced type-1 interferon production independently of Cereblon via suppression of the TRIF/IRF3 pathway
Millrine D, et al.
International Immunology, 28(6), 307-315 (2016)
Mitochondrial cereblon functions as a Lon-type protease
Kataoka K, et al.
Scientific reports, 6, 29986-29986 (2016)
David Millrine et al.
International immunology, 28(6), 307-315 (2016-02-13)
Thalidomide and its derivatives, collectively referred to as immunomodulatory drugs (IMiDs), are effective inhibitors of inflammation and are known to inhibit TLR-induced TNFα production. The identification of Cereblon as the receptor for these compounds has led to a rapid advancement
Functional modulation of AMP-activated protein kinase by cereblon
Lee KM et al.
Biochim. Biophys. Acta Gen. Subj., 1813(3) (2011)

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