一般描述
Complement factor properdin (CFP) gene is located on human chromosome Xp11.23. CFP is released by proinflammatory activated leukocytes, which interacts with activated platelets. CFP is also produced by T cells and bone marrow progenitor cell line. Plasma properdin is released by endothelial cells, when induced by shear stress. CFP consists of 442 amino acids.
免疫原
CFP (NP_002612.1, 1 a.a. ~ 469 a.a) full-length human protein.
Sequence
MITEGAQAPRLLLPPLLLLLTLPATGSDPVLCFTQYEESSGKCKGLLGGGVSVEDCCLNTAFAYQKRSGGLCQPCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQESEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGHRCAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCTPLLPKYPPTVSMVEGQGEKNVTFWGRPLPRCEELQGQKLVVEEKRPCLHVPACKDPEEEEL
Sequence
MITEGAQAPRLLLPPLLLLLTLPATGSDPVLCFTQYEESSGKCKGLLGGGVSVEDCCLNTAFAYQKRSGGLCQPCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQESEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGHRCAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCTPLLPKYPPTVSMVEGQGEKNVTFWGRPLPRCEELQGQKLVVEEKRPCLHVPACKDPEEEEL
生化/生理作用
Complement factor properdin (CFP) helps in energy and lipid metabolism. It regulates the uptake of fatty acid into adipose tissue. CFP upregulates the alternative pathway by stabilizing the C3 convertase (C3bBb) complex. Deficiency of properdin might be associated with immune complex-induced arthritis.
外形
Solution in phosphate buffered saline, pH 7.4
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Family-based genome-wide association study in Patagonia confirms the association of the DMD locus and cleft lip and palate
Fonseca R, et al.
European Journal of Oral Sciences, 123(5), 381-384 (2015)
Properdin and factor h: opposing players on the alternative complement pathway ?see-saw?
Kouser L, et al.
Frontiers in Immunology, 4, 93-93 (2013)
Identification of a novel mode of complement activation on stimulated platelets mediated by properdin and C3 (H2O)
Saggu G, et al.
Journal of immunology (Baltimore, Md. : 1950), 1300610-1300610 (2013)
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