SAB1409440
Anti-CFP antibody produced in mouse
purified immunoglobulin, buffered aqueous solution
别名:
BFD, PFC, PFD, PROPERDIN
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
3
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 51.3 kDa
species reactivity
human
technique(s)
western blot: 1 μg/mL
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CFP(5199)
General description
Complement factor properdin (CFP) gene is located on human chromosome Xp11.23. CFP is released by proinflammatory activated leukocytes, which interacts with activated platelets. CFP is also produced by T cells and bone marrow progenitor cell line. Plasma properdin is released by endothelial cells, when induced by shear stress. CFP consists of 442 amino acids.
Immunogen
CFP (NP_002612.1, 1 a.a. ~ 469 a.a) full-length human protein.
Sequence
MITEGAQAPRLLLPPLLLLLTLPATGSDPVLCFTQYEESSGKCKGLLGGGVSVEDCCLNTAFAYQKRSGGLCQPCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQESEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGHRCAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCTPLLPKYPPTVSMVEGQGEKNVTFWGRPLPRCEELQGQKLVVEEKRPCLHVPACKDPEEEEL
Sequence
MITEGAQAPRLLLPPLLLLLTLPATGSDPVLCFTQYEESSGKCKGLLGGGVSVEDCCLNTAFAYQKRSGGLCQPCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQESEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGHRCAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCTPLLPKYPPTVSMVEGQGEKNVTFWGRPLPRCEELQGQKLVVEEKRPCLHVPACKDPEEEEL
Biochem/physiol Actions
Complement factor properdin (CFP) helps in energy and lipid metabolism. It regulates the uptake of fatty acid into adipose tissue. CFP upregulates the alternative pathway by stabilizing the C3 convertase (C3bBb) complex. Deficiency of properdin might be associated with immune complex-induced arthritis.
Physical form
Solution in phosphate buffered saline, pH 7.4
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Identification of a novel mode of complement activation on stimulated platelets mediated by properdin and C3 (H2O)
Saggu G, et al.
Journal of immunology (Baltimore, Md. : 1950), 1300610-1300610 (2013)
Properdin and factor h: opposing players on the alternative complement pathway ?see-saw?
Kouser L, et al.
Frontiers in Immunology, 4, 93-93 (2013)
Family-based genome-wide association study in Patagonia confirms the association of the DMD locus and cleft lip and palate
Fonseca R, et al.
European Journal of Oral Sciences, 123(5), 381-384 (2015)
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