生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 27.2 kDa
种属反应性
human
技术
immunofluorescence: suitable
western blot: 1 μg/mL
NCBI登记号
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... OTUB2(78990)
一般描述
OTU ubiquitin aldehyde binding 2 (OTUB2) is a de-ubiquitinating enzyme, which belongs to the ovarian tumor protease (OTU) subfamily of deubiquitinylases. It has an ovarian tumor (OTU) domain. OTUB2 gene is mapped to human chromosome 14q32.
免疫原
OTUB2 (NP_075601.1, 1 a.a. ~ 234 a.a) full-length human protein.
Sequence
MSETSFNLISEKCDILSILRDHPENRIYRRKIEELSKRFTAIRKTKGDGNCFYRALGYSYLESLLGKSREIFKFKERVLQTPNDLLAAGFEEHKFRNFFNAFYSVVELVEKDGSVSSLLKVFNDQSASDHIVQFLRLLTSAFIRNRADFFRHFIDEEMDIKDFCTHEVEPMATECDHIQITALSQALSIALQVEYVDEMDTALNHHVFPEAATPSVYLLYKTSHYNILYAADKH
Sequence
MSETSFNLISEKCDILSILRDHPENRIYRRKIEELSKRFTAIRKTKGDGNCFYRALGYSYLESLLGKSREIFKFKERVLQTPNDLLAAGFEEHKFRNFFNAFYSVVELVEKDGSVSSLLKVFNDQSASDHIVQFLRLLTSAFIRNRADFFRHFIDEEMDIKDFCTHEVEPMATECDHIQITALSQALSIALQVEYVDEMDTALNHHVFPEAATPSVYLLYKTSHYNILYAADKH
生化/生理作用
OTU ubiquitin aldehyde binding 2 (OTUB2) possesses deubiquitinating enzymes (DUB) activity. It is capable of cleaving polyubiquitin chains, that are differently linked. It plays an important role in regulating the degradation of GLI family zinc finger 2 (Gli2) protein. OTUB2 can inhibit the death of human β cells. It is involved in immunity and viral infection. This protein can modulate nuclear factor κB (NF-κB) signaling pathway. OTUB2 might be associated with endometrial cancer.
外形
Solution in phosphate buffered saline, pH 7.4
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储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
此项目有
Dakshinamurthy Sivakumar et al.
The Journal of biological chemistry, 295(20), 6972-6982 (2020-04-09)
The ovarian tumor domain (OTU) deubiquitinylating cysteine proteases OTUB1 and OTUB2 (OTU ubiquitin aldehyde binding 1 and 2) are representative members of the OTU subfamily of deubiquitinylases. Deubiquitinylation critically regulates a multitude of important cellular processes, such as apoptosis, cell
Carol A Edwards et al.
BMC evolutionary biology, 7, 157-157 (2007-09-08)
The evolution of genomic imprinting, the parental-origin specific expression of genes, is the subject of much debate. There are several theories to account for how the mechanism evolved including the hypothesis that it was driven by the evolution of X-inactivation
A Beck et al.
Diabetologia, 56(6), 1317-1326 (2013-03-22)
Pro-inflammatory cytokines induce death of beta cells and hamper engraftment of transplanted islet mass. Our aim was to reveal novel genes involved in this process, as a platform for innovative therapeutic approaches. Small interfering RNA (siRNA) high-throughput screening (HTS) of
Xin-Yan Li et al.
Biochemical and biophysical research communications, 505(1), 113-118 (2018-09-23)
The transcription factor Gli2 plays crucial roles in the transduction of Hedgehog (Hh) signals, yet the mechanisms that control Gli2 degradation remain unclear. Here we have identified the eubiquitinating enzyme otubain2 (OTUB2) as a regulator of Gli2 protein degradation. We
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