SAB2102328
Anti-STUB1 antibody produced in rabbit
affinity isolated antibody
别名:
Anti-CHIP, Anti-HSPABP2, Anti-NY-CO-7, Anti-SDCCAG7, Anti-STIP1 homology and U-box containing protein 1
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
35 kDa
species reactivity
horse, rat, bovine, human, dog, guinea pig, mouse
concentration
0.5 mg - 1 mg/mL
technique(s)
immunohistochemistry: suitable, western blot: suitable
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... STUB1(10273)
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General description
STUB1 (STIP1 homology and U-box containing protein 1) codes for CHIP (C-terminus of HSC70-interacting protein). It is located on human chromosome 16p13.3.
Immunogen
Synthetic peptide directed towards the C terminal region of human STUB1
Biochem/physiol Actions
STUB1 modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. It has E3 ubiquitin-protein ligase activity and targets misfolded chaperone substrates towards proteasomal degradation. STUB1 mediates the transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation.
Mutations in STUB1 (STIP1 homology and U-box containing protein 1) result in autosomal recessive cerebellar ataxia (ARCA). The carboxyl terminus of the Hsc70?interacting protein (CHIP) has the ability to stimulate ubiquitination and degradation of various oncogenic proteins. It also plays a vital role in blocking tumor progression and invasion.
Mutations in STUB1 (STIP1 homology and U-box containing protein 1) result in autosomal recessive cerebellar ataxia (ARCA). The carboxyl terminus of the Hsc70?interacting protein (CHIP) has the ability to stimulate ubiquitination and degradation of various oncogenic proteins. It also plays a vital role in blocking tumor progression and invasion.
Physical form
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Other Notes
Synthetic peptide located within the following region: VDEKRKKRDIPDYLCGKISFELMREPCITPSGITYDRKDIEEHLQRVGHF
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
STUB1/CHIP mutations cause Gordon Holmes syndrome as part of a widespread multisystemic neurodegeneration: evidence from four novel mutations
Hayer SN, et al.
Orphanet Journal of Rare Diseases, 12(1), 31-31 (2017)
Prognostic value of the ubiquitin ligase carboxyl terminus of the Hsc70-interacting protein in postmenopausal breast cancer
Kurozumi S, et al.
Cancer Medicine, 5(8), 1873-1882 (2016)
Choreoathetosis, dystonia, and myoclonus in 3 siblings with autosomal recessive spinocerebellar ataxia type 16
Kawarai T, et al.
JAMA Neurology, 73(7), 888-890 (2016)
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