SAB2500458
Anti-GCNT3 (AA 410-422) antibody produced in goat
affinity isolated antibody, buffered aqueous solution
别名:
Anti-C2/4GnT, Anti-C2GnT-M, Anti-C2GnT2, Anti-N-Acetylglucosaminyltransferase 3
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i), WB
Citations:
4
biological source
goat
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
rat, human, mouse, canine
technique(s)
indirect ELISA: suitable, western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... GCNT3(9245)
General description
The GCNT3 (glucosaminyl (N-acetyl) transferase 3, mucin type) gene codes for an enzyme synthesizing the core of mucin protein and is mapped to human chromosome 15q22.2. The enzyme is predominantly expressed in stomach and colon.
Immunogen
Peptide with sequence C-NKFDPKVDDNALQ from the internal region (near C terminus) of the protein sequence according to NP_004742.1.
Biochem/physiol Actions
Gcnt3 (glucosaminyl (N-acetyl) transferase 3, mucin type) is involved in the biosynthesis of core 2, core 4 and blood group I antigen in secreted mucins. Overexpression of GCNT3 gene is observed in human pancreatic cancer and contributes to elevated mucin formation, aggressive tumorigenesis and decreased patient survival. The GCNT3 gene is known to promote cell proliferation and spheroid formation in tumors. Deletion of GCNT3 gene results in loss of core 2 O-glycan in the stomach and colon.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
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Warning
hcodes
pcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Molecular Pathways: Mucins and Drug Delivery in Cancer.
Chinthalapally V R, et al.
Clinical Cancer Research (2017)
Keratin 1 Plays a Critical Role in Golgi Localization of Core 2 N-Acetylglucosaminyltransferase M via Interaction with Its Cytoplasmic Tail.
Armen P, et al.
The Journal of Biological Chemistry, 290(10), 6256-6269 (2015)
Core 2 Mucin-Type O-Glycan Is Related to EPEC and EHEC O157:H7 Adherence to Human Colon Carcinoma HT-29 Epithelial Cells.
Jun Y, et al.
Digestive Diseases and Sciences, 60(7), 1977?1990-1977?1990 (2015)
Allelic Skewing of DNA Methylation Is Widespread across the Genome.
Leonard C S, et al.
American Journal of Human Genetics, 86(2), 196-212 (2010)
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